[Some properties of auditory neuron's model trained by firing caused by tones modulated by low-frequency noise].

In many sensory systems the formation of burst firing can be observed along a way from the periphery to the central nuclei. We investigate the putative transformation of spontaneous activity in the auditory pathway using a neuron model trained by real firing recorded in the auditory nuclei of the frog. The model has 200 separate inputs (neuronal spines).

[A relationship of congenital brain malformations and tumor growth].

The peritumor-like areas of 12 cerebral hemispheric tumors were examined. Histological study revealed vascular malformations and/or congenital tissue dysplasias in all cases: cortical disorganization, neuronal heterotopy into the white matter, neural location in the molecular cortical layer, and persistence of a subpial granular cell layer. Immunohistochemical study using Ki-67 antibodies in the peritumor-like tissue dysplasias revealed proliferative activity in a number of cases.

[Calorimetric study of the helix-coil transition in DNA during interaction with Cu2+ ions].

Using the method of differential scanning calorimetry, the DNA helix-coil transition was studied in solutions (10(-3) M Na+, 10(-3) M tris HCl, pH 7.0) containing divalent copper ions at relative metal ion concentrations (Mt2+/PDNA) ranging from 0.2 to 20.

[Calorimetric study of Ca2+ and Mn2+ ions' effect on DNA helix-coil transition].

Using the method of differential scanning calorimetry, the DNA helix-coil transition studied in solutions (10(-3) M Na+, 10(-3) M tris HCl, pH 7.0) containing divalent metal ions (Mn2+ and Ca2+) at relative metal ion concentrations (Me/PDNA) ranging from 0.2 to 20.

[Effect of low temperatures on molecular parameters of DNA].

Cryoconservation effects on macromolecular parameters of DNA from reproductive cells of fishes are studied as well as cryodamages of DNA in solutions under various freezing conditions, by the viscometry method. A dependence of the low temperature action on DNA concentration in solution and on the action duration is determined. It is stated as well that the nitrogen temperature action on the biopolymer solution results in the formation of both double- and single-stranded breaks.

[Relation between the conformation and antioxidant properties in a series of topochemical analogs of carnosine and carcinine with different N-acyl substitutes].

To elucidate the influence of the nature of N-acyl substituent on antioxidant properties of carcinine analogs, the corresponding histamine derivatives were synthesized. Antioxidant activity of the compounds prepared was investigated in the Fe(2+)-ascorbate-dependent system of oxidation of the linoleic acid micellar solution. Conformations of carnosine, carcinine, and their analogs were calculated by the molecular mechanics MM+ method.

[Structural and physicochemical characteristics of DNA from animal tissue subjected to chronic irradiation in the Chernobyl area].

The properties of animal DNAs exposed to prolonged irradiation in the Chernobyl zone, have been studied by the methods of viscometry, thermal denaturation, IR-spectroscopy, and electrophoresis. High content of low-molecular fractions have been observed in the preparations of DNA from liver and spleen, their quantities increasing with age and generation of animals. This effect is especially strong in DNA from liver.

[The disseminated intravascular coagulation syndrome in endotoxin shock].

Dynamics of blood coagulation and morphological changes after the intravenous administration of Salmonella typhimurium endotoxin is studied experimentally in Chinchilla rabbits. The stages of blood coagulation are established characteristic for the above syndrome. The signs of the developing blood stasiopathy with the domination of vascular wall damage and thrombocyte aggregation are observed.

[Astrocytic glia in the pathogenesis of Creutzfeldt-Jakob disease].

The role of astrocytes in pathogenesis of Creutzfeld-Jakob disease (CJD), one of the slow virus infections of human central nervous system caused by an unconventional virus (prion) has been studied. Histological and ultrastructural examinations of the brain of both dead people and experimentally infected guinea pigs, combined with the data on morphofunctional state of infected monolayer glial culture analysis have shown astrocytes, as well as neurons, to be target-cells for the causative agent of the disease. The astrocyte changes observed were evaluated as proliferative-degenerative ones with the activation prevailing over the cell destruction.

[Clinico-laboratory and pathomorphologic study of intravascular blood coagulation syndrome in experimental amniotic embolism].

The time-course of hemocoagulative and morphological changes affected by intravenous administration of amniotic fluids was examined in experiments on Chinchilla rabbits weighing 2.0-2.5 kg.