Publications by authors named "Griffin White"
Article Synopsis
- The study explores access to CART19 immunotherapy for large B-cell lymphomas among minority health populations (MHPs) compared to non-MHPs in different hospital settings.
- It found that while MHPs had access to care for LBCL, their representation in CART19 therapy was lower, with only 6.7% at the Abramson Cancer Center and 4.2% at the Knight Cancer Institute receiving the treatment.
- Outcomes for MHPs who did receive CART19 were similar to non-MHPs regarding response and survival, but the small sample size necessitates further research to confirm these findings.
Bendamustine has been retrospectively shown to be an effective and safe lymphodepletion regimen prior to the anti-CD19 chimeric antigen receptor T cell (CART) products tisagenlecleucel and axicabtagene ciloleucel, as well as the anti-BCMA CART products idecabtagene vicleucel and ciltacabtagene autoleucel. However, bendamustine as lymphodepletion prior to lisocabtagene maraleucel (liso-cel), a 4-1BB co-stimulated, fixed CD4:CD8 ratio anti-CD19 CART product, has not been described yet. Thus, we studied a cohort of sequentially-treated patients with large B-cell lymphomas who received bendamustine lymphodepletion before liso-cel at the University of Pennsylvania between 5/2021 and 12/2023 (n = 31).
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- This study focuses on the need for efficient and cost-effective methods to measure important characteristics of CAR T cells during their manufacturing process, as the popularity of these therapies is rising.
- Researchers compared a new device called the Moxi GO II with established devices, the Multisizer Coulter Counter and BD LSRFortessa, to evaluate cell number, size, viability, and basic features of CAR T cells.
- Findings show that the Moxi GO II can accurately provide these measurements and is comparable to the gold standard instruments, making it a promising tool for monitoring CAR T-cell characteristics in both research and clinical settings.
Hematologic malignancies disproportionately affect older adults. Hematopoietic cell transplantation (HCT) is potentially curative, but poor overall survival (OS) has limited its use in older adults. Fried's frailty phenotype (FFP) is a geriatric assessment tool that combines objective and subjective performance measures: gait speed, grip strength, activity level, exhaustion, and weight loss.
View Article and Find Full Text PDFLymphodepletion (LD) is an integral component of chimeric antigen receptor T-cell (CART) immunotherapies. In this study, we compared the safety and efficacy of bendamustine (Benda) to standard fludarabine/cyclophosphamide (Flu/Cy) LD before CD19-directed, CD28-costimulated CART axicabtagene ciloleucel (axi-cel) for patients with large B-cell lymphoma (LBCL) and follicular lymphoma (FL). We analyzed 59 patients diagnosed with LBCL (n = 48) and FL (n = 11) consecutively treated with axi-cel at the University of Pennsylvania.
View Article and Find Full Text PDFBackground: In December 2020, the United Kingdom (UK) reported a SARS-CoV-2 Variant of Concern (VoC) which is now named B.1.1.
View Article and Find Full Text PDFGenome-wide genotyping and Bayesian inference method (BORICE) were employed to estimate outcrossing rates and paternity in two small plant populations of (Asteraceae) on Graciosa island in the Azores. These two known extant populations of on Graciosa have recently evolved self-compatibility. Despite the expectation that selfing would occur at an appreciable rate (self-incompatible populations of the same species show low but nonzero selfing), high outcrossing was found in progeny arrays from maternal plants in both populations.
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