Glioma assessment using quantitative blood volume maps generated by T1-weighted dynamic contrast-enhanced magnetic resonance imaging: a receiver operating characteristic study.

Purpose: To investigate the use of blood volume maps in the non-invasive separation of glioma grades.

Material And Methods: T1-weighted quantitative dynamic contrast-enhanced magnetic resonance imaging was used to quantify the fractional intratumoral blood volume of 41 gliomas (World Health Organization (WHO) grades II-IV). Two methods, mean fractional intratumoral blood volume determination and a system based on thresholds for extracting the tumor pixels with the highest vascularization from the blood volume maps, were investigated by means of receiver operating characteristic (ROC) analysis.

BOLD signal in the motor cortex shows a correlation with the blood volume of brain tumors.

Purpose: To investigate whether and how the blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) signal is modified by brain tumors.

Materials And Methods: The BOLD signal depends on the perfusion, which in turn may be affected in the presence of a tumor. Some studies have demonstrated a reduced BOLD signal in the tumor-bearing hemisphere.

Quantitative measurement of leakage volume and permeability in gliomas, meningiomas and brain metastases with dynamic contrast-enhanced MRI.

The spatial properties and function of the tumor vasculature differ with the tumor type and grade. T1-weighted dynamic contrast-enhanced imaging technique enables the simultaneous quantification of some functional parameters of the vasculature. These are the fractional contrast-enhancing volumes of the tissue compartments (blood volume and leakage/extravascular extracellular volume) and the exchange parameters (perfusion and permeability).

Comparison of dynamic contrast-enhanced MRI with WHO tumor grading for gliomas.

Assessment of vascular proliferation as an important grading criterion has been employed in both the histologic and the radiologic characterization of gliomas with encouraging results. Perfusion in gliomas can be measured by dynamic contrast-enhanced magnetic resonance imaging (dMRI). The goal of this study was to develop a model for simultaneously quantifying the fractional volumes of different tissue compartments of gliomas by dMRI.