Publications by authors named "Gribson Chan"
Article Synopsis
- The study analyzed data from a randomized controlled trial examining the effects of multi-domain lifestyle interventions on frail elderly individuals over 6 months.
- Key improvements included reduced sarcopenia, increased lower limb strength, and faster gait speed, with significant changes noted for both sarcopenic and non-sarcopenic participants.
- The interventions also led to notable reductions in inflammation levels and positive changes in blood biomarkers linked to muscle metabolism, hormone regulation, and tissue oxygenation.
Importance: There is little understanding of the outcomes associated with active lifestyle interventions for sarcopenia among older persons.
Objective: To determine the association of 6-month multidomain lifestyle interventions (physical exercise, nutritional enhancement, cognitive training, combined treatment, and standard care) with change in sarcopenia status and physical function among adults 65 years and older.
Design, Setting, And Participants: Post hoc secondary analysis of a parallel-group randomized clinical trial conducted from September 1, 2012, to September 1, 2014, at community centers providing services to elderly individuals in Singapore.
Background: Cognitive, physical, and nutritional interventions may produce different cognitive effects for different groups of older persons. We investigated simultaneously the cognitive outcomes of cognitive, physical, and nutritional interventions singly and in combinations in older persons with the physical frailty phenotype at particular risk of cognitive decline.
Method: Pre-frail and frail participants were randomly allocated to 24 weeks nutritional supplementation (N = 49), physical training (N = 48), cognitive training (N = 50), combination intervention (N = 49), or usual care control (N = 50).
Background: It is important to establish whether frailty among older individuals is reversible with nutritional, physical, or cognitive interventions, singly or in combination. We compared the effects of 6-month-duration interventions with nutritional supplementation, physical training, cognitive training, and combination treatment vs control in reducing frailty among community-dwelling prefrail and frail older persons.
Methods: We conducted a parallel group, randomized controlled trial in community-living prefrail and frail old adults in Singapore.
Integrated care pathway for hip fractures in a subacute rehabilitation setting.
Ann Acad Med Singap
November 2013
Introduction: The effectiveness of integrated care pathways for hip fractures in subacute rehabilitation settings is not known. The study objective was to assess if a hip fracture integrated care pathway at a subacute rehabilitation facility would result in better functional outcomes, shorter length of stay and fewer institutionalisations.
Materials And Methods: A randomised controlled trial on an integrated care pathway for hip fracture patients in a subacute rehabilitation setting.
Background: The effects of depression and cognitive impairment on hip fracture rehabilitation outcomes are not well established. We aimed to evaluate the associations of depressive symptoms and cognitive impairment (individually and combined) with ambulatory, living activities and quality of life outcomes in hip fracture rehabilitation patients.
Methods: A cohort of 146 patients were assessed on depressive symptoms (Geriatric Depression Scale, GDS > or = 5), cognitive impairment (Mini-mental State Examination, MMSE < or = 23), and other variables at baseline, and on ambulatory status, Modified Barthel Index (MBI), and SF-12 PCS and MCS quality of life on follow ups at discharge, 6 months and 12 months post fracture.