Publications by authors named "Gretta D Kellogg"
Article Synopsis
- Reproducibility poses significant challenges in (epi)genomic research due to complex experiments and the high-speed generation of sequencing data.
- The Platform for Epi-Genomic Research (PEGR) is introduced as a web-based tool for managing and quality controlling experiments from start to finish.
- PEGR enhances rigor and reproducibility for both biochemists and bioinformaticians, thanks to its compatibility with various assays and integration with the Galaxy platform.
The genome-wide architecture of chromatin-associated proteins that maintains chromosome integrity and gene regulation is not well defined. Here we use chromatin immunoprecipitation, exonuclease digestion and DNA sequencing (ChIP-exo/seq) to define this architecture in Saccharomyces cerevisiae. We identify 21 meta-assemblages consisting of roughly 400 different proteins that are related to DNA replication, centromeres, subtelomeres, transposons and transcription by RNA polymerase (Pol) I, II and III.
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