Publications by authors named "Gretillat P"

Short description of the technique of fixing material--obtained by percutaneous fine needle biopsy--for cytology. A well experienced cytopathologist is mandatory for interpretation of the specimen.

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Percutaneous biopsy of the pancreas with a fine needle aimed by ultrasound was carried out on 26 patients with sonographically proven carcinoma of the pancreas. The accuracy of this method was correlated with other radiological techniques. Needle biopsy of the pancreas proved an informative and economical procedure, since the sonographic demonstration of a pancreatic mass otherwise requires additional radiological and endoscopic investigations.

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Of 47 children with an initial diagnosis of lymphosarcoma, reticulosarcoma or Non-Hodgkin's lymphoma (NHL), 13 had to be excluded at the histologic reevaluation: in 10 an undifferentiated sarcoma, in 2 Hodgkin lymphoma was found; in one patient no definite classification of the tumor was possible. Of the remaining 34 patients there were 26 boys and 8 girls. One patient had a nodular, 33 a diffuse NHL.

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In a prospective study 96 patients with esophageal and gastric lesions were investigated by multiple endoscopic biopsy, brush cytology, and guided lavage cytology. The aim was to evaluate the diagnostic accuracy of each of these methods in a prospective study. 50 malignant and 46 benign lesions were found.

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The case of a 28-year-old female patient is presented. Heavy infiltration with plasma cells of uterine tissue removed by surgical currettage following an aborted pregnancy was detected by cytological and histological examination. Subsequent immunohistochemical studies revealed the monoclonal nature of these cells: intracellular immunoglobulin contained gamma- and lambda-chains exclusively.

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The value of multiple biopsies and brush cytology at oesophago-gastroscopy was assessed in relation to macroscopy and localization on 100 verified tumours in a prospective study. The cumulative accuracy achieved was 96%. This was significantly better (P less than 0-01) than that of biopsy (83%) and of cytology (85%).

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The evaluation of smears of the uterine cervix on the basis of descriptive terms requires the practitioner to be acquainted with the nomenclature used by cytologists. A theoretical scheme is provided which correlates the diagnostic features encountered with their respective clinical implications.

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Smears from the uterine cervix have been evaluated for neoplastic changes on the basis of descriptive terms. The material was obtained by a single gynecologist using a standardized sampling technique and the results were compared with the respective histological diagnoses. Material which was found to be unsuitable for technical reasons was excluded from this study.

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