Publications by authors named "Gretel R Rodriguez"
Cervical cancer, which main etiologic factor is Human Papillomavirus (HPV) infection, continues to be a burden for public health systems in developing countries. Our laboratory has been working with the hypothesis that signals generated in the tumor microenvironment can modulate local and systemic immune responses. In this context, it would be reasonable to think that tumors create pro-tumoral bias in immune cells, even before they are recruited to the tumor microenvironment.
View Article and Find Full Text PDFThe granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that has important clinical applications for treating neutropenia. Nartograstim is a recombinant variant of human G-CSF. Nartograstim has been produced in Escherichia coli as inclusion bodies (IB) and presents higher stability and biological activity than the wild type of human G-CSF because of its mutations.
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- Monocytes are crucial for maintaining homeostasis and fighting infection, and their recruitment to inflammatory sites is vital for controlling tissue damage and aiding T cell responses.
- NFAT1 plays a significant role in the migration of Ly6C inflammatory monocytes to the central nervous system (CNS) during infection; monocytes lacking NFAT1 can't migrate effectively.
- The absence of NFAT1 leads to increased susceptibility to chronic infection as it impairs parasite control in the CNS, and introducing Ly6C monocytes into NFAT1-deficient mice enhances CD4 T cell migration, aiding host defense.