Publications by authors named "Greta Tellkamp"
Eur J Cell Biol
December 2024
Article Synopsis
- The study investigates the role of endosomal SNARE proteins Vti1a and Vti1b in neuronal development, highlighting their importance for membrane fusion and neurite outgrowth.
- In a mouse model and using CRISPR/Cas9, the researchers created a double knockout of these proteins in neuroblastoma cells, which showed impaired differentiation and reduced neurite formation compared to normal cells.
- The findings indicate that the absence of these SNARE proteins hinders critical signaling pathways involved in neurite elongation, specifically affecting responses to neurotrophic factors and signaling cascades like Akt and Erk.
