The Role of Motion Sensitivity and Headaches on Vestibular Rehabilitation Outcomes in Pediatric Vestibular Migraines.

Objective: To determine the utility of the motion sensitivity quotient (MSQ) in diagnosing pediatric vestibular migraine (VM) and to characterize the role of motion sensitivity and headache control on vestibular rehabilitation (VR) outcomes in pediatric VM.

Study Design: Retrospective cohort analysis.

Setting: Pediatric tertiary referral center.

Cortical processing of location and frequency changes of sounds in normal hearing listeners.

Sounds we hear in our daily life contain changes in the acoustic features (e.g., frequency, intensity, and duration or "what" information) and/or changes in location ("where" information).

Socioeconomic Disparities in Pediatric Single-Sided Deafness.

Objective: To explore socioeconomic disparities in pediatric single-sided deafness (SSD) treatment.

Study Design: Retrospective chart review.

Setting: Tertiary referral academic center.

The Clinical Journey of Patients with Riboflavin Transporter Deficiency Type 2.

Purpose: To identify symptoms and health care interactions with patients with riboflavin transporter deficiency (RTD) type 2 prior to diagnosis.

Methods: Parents of children with riboflavin transporter deficiency type 2 (n = 10) were interviewed to collect data on the patient's clinical journey.

Results: The average diagnostic delay was 27.

International Pediatric Otolaryngology Group (IPOG) Consensus Recommendations: Congenital Cholesteatoma.

Objective: To provide recommendations to otolaryngologists and allied physicians for the comprehensive management of children who present with signs and symptoms of congenital cholesteatoma.

Methods: A two-iterative Delphi method questionnaire was used to establish expert recommendations by the members of the International Pediatric Otolaryngology Group, on the preoperative work-up, the perioperative considerations, and follow-up.

Results: Twenty-two members completed the survey, in 14 tertiary-care center departments representing 5 countries.

Consensus interpretation of the p.Met34Thr and p.Val37Ile variants in GJB2 by the ClinGen Hearing Loss Expert Panel.

Purpose: Pathogenic variants in GJB2 are the most common cause of autosomal recessive sensorineural hearing loss. The classification of c.101T>C/p.

Imaging findings in pediatric single-sided deafness and asymmetric hearing loss.

Objective: To examine the imaging findings on computer tomography (CT) and magnetic resonance imaging (MRI) in pediatric single-sided deafness (SSD) and asymmetric hearing loss (ASH).

Methods: The medical records of 189 pediatric patients with SSD and ASH were retrospectively reviewed, and imaging findings were compared. SSD was defined as unilateral profound hearing loss and contralateral normal hearing ear.

The Girl With the Bleeding Earlobe Mass.

Pilomatrixomas, also known as epithelioma calcificans, are benign tumors of hair follicle matrix cells that are often mistaken for other lesions, especially cutaneous abscesses. We report an illustrative case in which a teenage girl developed a red, swollen earlobe that required multiple care visits and interventions until definitive diagnosis and treatment were provided. Although the lesion was initially treated as an abscess, it continued to progress in size and discomfort.

Ocular Vestibular Evoked Myogenic Potentials: Normative Findings in Children.

Background: To add to the limited body of literature on ocular vestibular evoked myogenic potential (oVEMP) responses in children and to assess a different montage for oVEMP recording.

Purpose: To evaluate the characteristics of the oVEMP response in children and compare the results with that of a group of healthy adults.

Research Design: Prospective descriptive study from a tertiary referral center.

Diagnostic Evaluation of Children with Sensorineural Hearing Loss.

The cause of pediatric sensorineural hearing loss is diverse, comprising genetic, acquired, and idiopathic conditions. Identifying the specific cause requires that children undergo thorough otolaryngologic and audiometric evaluations, which generally include laboratory tests and temporal bone imaging studies. Clinical genetics and ophthalmologic consultations are also frequently warranted.

High-frequency sensorineural hearing loss in children.

Objectives/hypothesis: Determine the prevalence of high-frequency sensorineural hearing loss (HFSNHL) in our hearing loss population and a diagnostic algorithm for these patients.

Study Design: Retrospective case series.

Methods: We identified patients diagnosed with sensorineural hearing loss (SNHL) at our pediatric tertiary care institution from 1981 to 2010.

Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss.

Pathogenic mutations of MARVELD2, encoding tricellulin, a tricelluar tight junction protein, cause autosomal recessive non-syndromic hearing loss (DFNB49) in families of Pakistan and Czech Roma origin. In fact, they are a significant cause of prelingual hearing loss in the Czech Roma, second only to GJB2 variants. Previously, we reported that mice homozygous for p.

Mutation analysis of the SLC26A4, FOXI1 and KCNJ10 genes in individuals with congenital hearing loss.

Pendred syndrome (PDS) and DFNB4 comprise a phenotypic spectrum of sensorineural hearing loss disorders that typically result from biallelic mutations of the SLC26A4 gene. Although PDS and DFNB4 are recessively inherited, sequencing of the coding regions and splice sites of SLC26A4 in individuals suspected to be affected with these conditions often fails to identify two mutations. We investigated the potential contribution of large SLC26A4 deletions and duplications to sensorineural hearing loss (SNHL) by screening 107 probands with one known SLC26A4 mutation by Multiplex Ligation-dependent Probe Amplification (MLPA).

Codeine-related adverse drug reactions in children following tonsillectomy: a prospective study.

Objectives/hypothesis: To prospectively determine factors associated with codeine's adverse drug reactions (ADRs) at home in a large homogenous population of children undergoing outpatient tonsillectomy.

Study Design: Prospective, genotype blinded, observational study with a single group and repeated ADR measures documented by parents at home.

Methods: A total of 249 children 6 to 15 years of age scheduled for tonsillectomy were enrolled.

Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss.

Objective: To identify the genetic cause of prelingual sensorineural hearing loss in Pakistani families using a next-generation sequencing (NGS)-based mutation screening test named OtoSeq.

Study Design: Prospective study.

Setting: Research laboratory.

Performance evaluation of the next-generation sequencing approach for molecular diagnosis of hereditary hearing loss.

Objective: To evaluate the performance of a next-generation sequencing (NGS)-based targeted resequencing genetic test, OtoSeq, to identify the sequence variants in the genes causing sensorineural hearing loss (SNHL).

Study Design: Retrospective study.

Setting: Tertiary children's hospital.

Significance of unilateral enlarged vestibular aqueduct.

Objectives/hypothesis: To describe the clinical phenotype of pediatric patients with unilateral enlarged vestibular aqueduct (EVA) and then to compare the findings to two clinically related phenotypes: bilateral EVA and unilateral hearing loss without EVA. In view of clinical observations and previously published data, we hypothesized that patients with unilateral EVA would have a much higher rate of contralateral hearing loss than patients with unilateral hearing loss without EVA.

Study Design: Retrospective cohort study.

Minimal access and standard cochlear implantation: a comparative study.

Objective: To compare the operative times and complications between patients who underwent minimal access cochlear implantation and standard technique cochlear implantation.

Methods: Patients who underwent unilateral cochlear implantation by a single surgeon from 2001 to 2010. The minimal access technique of an approximately 2.

To tube or not to tube: indications for myringotomy with tube placement.

Purpose Of Review: To examine the current indications for myringotomy with tube placement.

Recent Findings: In 2004, revised clinical practice guidelines for otitis media with effusion (OME) and acute otitis media (AOM) were published. Because of the rate of spontaneous resolution of otitis in children, these guidelines suggest more 'watchful waiting' in both disease processes.

Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding.

Objective: To determine the prevalence of coagulopathy among children presenting with posttonsillectomy bleeding (PTB) and describe risk factors that could indicate the presence of occult coagulopathy.

Design: Retrospective medical chart review.

Setting: Tertiary-care pediatric hospital.

Genetic mutations and aminoglycoside-induced ototoxicity in neonates.

Objective: Mutations in the 12S rRNA gene have been associated with aminoglycoside-induced ototoxicity. Our objective was to study the relationship of these mutations in neonates, duration of aminoglycoside exposure, and other known risk factors to the presence of hearing loss.

Study Design: Prospective case-cohort study.

H1N1 influenza A presenting as bacterial tracheitis.

Six cases of bacterial tracheitis (BT) occurring early in the 2009 flu season have been isolated in conjunction with the H1N1 strain of influenza A (H1N1). No previous H1N1 cases have presented as BT in the literature to date. We would like to discuss viral coinfection in BT patients and how this new strain may affect the rate and type of presentation encountered.