Publications by authors named "Gregory Thomas Brown"
Article Synopsis
- Osteosarcoma is a serious bone cancer with limited biomarkers for personalized treatment, more common in adult dogs than humans; this study analyzed tumor data from both species to find shared patterns of disease progression.* -
- Researchers examined transcriptomic data from 245 dogs with osteosarcoma, identifying three tumor microenvironment (TME) subtypes: Immune Enriched, Immune Enriched Dense Extra-Cellular Matrix-like, and Immune Desert, which relate to survival rates.* -
- The study's findings suggest that insights from canine osteosarcoma can help enhance the understanding of the human form, potentially leading to better biomarkers and innovative treatment strategies in precision oncology.*
Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The term encompasses several patterns of liver injury, including a relatively benign condition of steatosis without hepatocellular injury, nonalcoholic steatohepatitis (NASH), and a pattern of zone 1 steatosis, inflammation and fibrosis mainly observed in prepubertal children. Staging and grading systems have been developed to characterize the histological changes in NAFLD, mainly as a tool for clinical research.
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- Distant cutaneous metastases of prostate cancer are very rare, with less than 0.1% of cases showing this occurrence compared to other cancers.
- Many cases of skin involvement are mistaken for other conditions, making it hard to recognize as prostate cancer.
- A thorough clinical history and high suspicion are essential for diagnosing cutaneous metastases in patients with a history of prostate cancer.