Publications by authors named "Gregory Thielman"

Article Synopsis
  • * Researchers analyzed MRI scans from 501 stroke patients to assess regional brain-PAD and lesion loads, discovering that larger stroke lesions correlate with older brain-PAD in the affected areas and younger brain-PAD in the opposite hemisphere.
  • * The findings highlight that the severity of stroke damage is linked to poorer motor function, with machine learning models identifying specific brain regions and lesion characteristics as key predictors of motor outcomes.
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Background And Purpose: Since the COVID-19 pandemic, the use and implementation of telehealth has expanded, with implementation moving ahead of best practice recommendations due to necessity. Telehealth has improved access and care coordination for patients with various neurologic conditions; however, information regarding therapeutic intensity, safety, and appropriateness is lacking. In 2021, the Academy of Neurologic Physical Therapy formed a Telehealth Taskforce to provide clinical and educational resources for its members and the neurologic physical therapy (PT) community.

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Article Synopsis
  • Accurate lesion segmentation is essential for quantifying stroke-related damage and improving image processing, but current automated methods for T1-weighted MRIs remain unreliable.
  • Manual segmentation is the standard but is labor-intensive and requires specialized knowledge.
  • The newly released ATLAS v2.0 dataset, which includes 1,271 T1-weighted MRIs and segmented lesion masks, aims to enhance algorithm development and provide better evaluation through hidden datasets for more effective stroke research.
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Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment.

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Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits.

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The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data.

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Background: With increased practice of real-time ultrasound imaging in the physical therapy profession, it is essential to evaluate the utility of its use post stroke.

Objective: Evaluate relationship of spastic brachialis muscle architectural parameters with clinical measures of upper extremity function and spasticity.

Methods: Eleven post stroke individuals with spasticity of the upper limb had their brachialis muscle pennation angle and fascicle length measured in the affected and unaffected upper arm, at rest.

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Background And Purpose: For individuals poststroke, reaching with the paretic limb is often associated with compensatory trunk movement due to limited active arm movement. We conducted a pilot feasibility study to compare the effects of task-related training on reaching with the paretic limb using each of 2 different techniques for providing feedback about trunk position. We hypothesized that the use of an auditory feedback signal in response to pressure (Sensor group) would be more effective than feedback arising from an external device used to restrain the trunk (Stabilizer group).

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Background And Purpose: Task-related training (TRT) but not resistive exercise (RE) was found to improve the path of the hand of a hemiparetic upper extremity when reaching to targets. Forward movement of the trunk, however, compensated for the poststroke motor impairment. Prior studies also demonstrated that short-term practice of reaching to grasp objects with truncal motion restrained (compared to unrestrained practice) increased elbow extension, lessened compensatory trunk movement, and improved interjoint coordination during performance with the trunk unrestrained.

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Background: Seated posture and trunk control are important factors affecting upper extremity (UE) function of wheelchair users. A stable pelvis and trunk are required to provide a base from which UE movement occurs, but, conversely, the ability to move one's trunk and pelvis can increase functional ranges of motion. For wheelchair users, balancing sufficient trunk support with adequate trunk mobility has important functional and medical consequences.

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