Publications by authors named "Gregory T Brown"

Article Synopsis
  • Osteosarcoma is a serious bone cancer with limited biomarkers for personalized treatment, more common in adult dogs than humans; this study analyzed tumor data from both species to find shared patterns of disease progression.* -
  • Researchers examined transcriptomic data from 245 dogs with osteosarcoma, identifying three tumor microenvironment (TME) subtypes: Immune Enriched, Immune Enriched Dense Extra-Cellular Matrix-like, and Immune Desert, which relate to survival rates.* -
  • The study's findings suggest that insights from canine osteosarcoma can help enhance the understanding of the human form, potentially leading to better biomarkers and innovative treatment strategies in precision oncology.*
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Liquid-based cytology (LBC) is a reliable automated technique for the screening of Papanicolaou (Pap) smear data. It is an effective technique for collecting a majority of the cervical cells and aiding cytopathologists in locating abnormal cells. Most methods published in the research literature rely on accurate cell segmentation as a prior, which remains challenging due to a variety of factors, e.

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Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The term encompasses several patterns of liver injury, including a relatively benign condition of steatosis without hepatocellular injury, nonalcoholic steatohepatitis (NASH), and a pattern of zone 1 steatosis, inflammation and fibrosis mainly observed in prepubertal children. Staging and grading systems have been developed to characterize the histological changes in NAFLD, mainly as a tool for clinical research.

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Distant cutaneous metastases of prostate carcinomas are extremely rare, despite its high incidence and prevalence. Most cases are either a result of local extension, such as into seminal vesicles or distant metastases to bone. Few cases of true cutaneous metastatic prostate carcinoma exist in the literature.

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Intestinal inflammation is associated with epithelial damage and formation of mucosal wounds. Epithelial cells migration is required for wound closure. In inflammatory status, migrating epithelial cells are exposed to proinflammatory cytokines such as IFN-gamma.

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