Publications by authors named "Gregory Papastoitsis"
JCI Insight
December 2023
Article Synopsis
- IL-12 is a powerful cytokine that enhances both innate and adaptive immune responses against cancer, but its use has been limited due to toxicity from systemic delivery.
- The development of an anchored variant called ANK-101 allows for intratumoral (i.t.) administration, which creates a stable drug depot in tumors, leading to longer retention and greater therapeutic effects compared to unanchored IL-12.
- ANK-101 has shown significant antitumor activity in various mouse models, even in cases resistant to other therapies, and demonstrated good tolerance in macaques, suggesting it has strong potential for clinical use.
