Publications by authors named "Gregory McClain"
Article Synopsis
- - The study aimed to evaluate the effects of the COVID-19 pandemic on the health of people who inject drugs (PWID) using a collaborative data-sharing model established in 2021, which pooled data from multiple studies across North America.
- - Researchers analyzed data on various health indicators (like substance use treatment and mental health conditions) over four different time periods: pre-pandemic, early-pandemic, mid-pandemic, and late-pandemic, involving 6,213 PWID participants.
- - The results showed minimal changes in health indicators throughout the pandemic, suggesting stability possibly due to policy adjustments and resilience in support services for PWID, highlighting the potential of the data-sharing model for better health insights.
Article Synopsis
- Widespread sequencing has identified thousands of missense variants linked to diseases, creating a challenge in assessing their functional impact at scale.
- A new high-throughput imaging platform was developed to evaluate the effects of 3,448 missense variants across over 1,000 genes, revealing that mislocalization of proteins is a frequent outcome.
- Mislocalization affects about one-sixth of pathogenic variants and is mainly caused by issues with protein stability and membrane insertion, which can influence disease severity and help interpret uncertain variants.
Abdominal pains secondary to adhesions are a common complaint, but most surgeons do not perform surgery for this complaint unless the patient suffers from a bowel obstruction. The purpose of this evaluation was to determine if lysis of bowel adhesions has a role in the surgical management of adhesions for helping treat abdominal pain. The database of our patients with complex abdominal and pelvic pain syndrome (CAPPS) was reviewed to identify patients who underwent a laparoscopic lysis of adhesion without any organ removal and observe if they had a decrease in the amount of abdominal pain after this procedure.
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