Substaging of pT1 Urothelial Bladder Carcinoma Predicts Tumor Progression and Overall Survival.

Introduction: Limitations in tumor staging and the heterogeneous natural evolution of pT1 urothelial bladder carcinoma (UBC) make the choice of treatment challenging. We evaluated if histopathological substaging (pT1a, pT1b, and pT1c) helps predict disease recurrence, progression, and overall survival following transurethral resection of the bladder (TURB).

Methods: We included 239 consecutive patients diagnosed with pT1 UBC at TURB in a single institution since 2001.