Production of curie quantities of Ga with a medical cyclotron via the Zn(p,n)Ga reaction.

PET imaging with Ga-labeled tracers has seen a dramatic increase over the past five years primarily due to the increased accessibility of Ge/Ga generators, the availability of tracers with superb targeting properties for labeling, straightforward labeling procedures and the approval of these tracers by regulatory entities. Available Ge/Ga generators nominally deliver up to 1.85 GBq (50mCi) when fresh limiting production and distribution of Ga-labeled tracers to a few daily doses per generator.

Semi-automated production of ⁸⁹Zr-oxalate/⁸⁹Zr-chloride and the potential of ⁸⁹Zr-chloride in radiopharmaceutical compounding.

Interest in using (89)Zr is rapidly increasing for immuno-PET applications due to its unique characteristics and increased availability. The focus of this study was to develop an optimized semi-automated methodology for producing (89)Zr-oxalate/(89)Zr-chloride, and evaluate the potential application of (89)Zr-chloride for radiopharmaceutical compounding. The data presented herein will be useful for the production of (89)Zr-labeled radiopharmaceuticals and their compliance with regulatory issues for both preclinical and clinical use.