Publications by authors named "Gregory J Frazier"
Importance: Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed as an alternative.
Objective: To compare the effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock.
Design, Setting, And Participants: A factorial (2×2), double-blind, randomized clinical trial conducted in 18 general adult intensive care units in the United Kingdom between February 2013 and May 2015, enrolling adult patients who had septic shock requiring vasopressors despite fluid resuscitation within a maximum of 6 hours after the onset of shock.