Multiple expressions of "expert" abnormality gist in novices following perceptual learning.

With a brief half-second presentation, a medical expert can determine at above chance levels whether a medical scan she sees is abnormal based on a first impression arising from an initial global image process, termed "gist." The nature of gist processing is debated but this debate stems from results in medical experts who have years of perceptual experience. The aim of the present study was to determine if gist processing for medical images occurs in naïve (non-medically trained) participants who received a brief perceptual training and to tease apart the nature of that gist signal.

Mortality Associated With Opioid Overdose: A Review of Clinical Characteristics and Health Services Received in the Year Prior to Death.

Objective: To assess missed opportunities for reducing fatal opioid overdoses, characteristics of decedents by opioid overdose with and without problematic opioid use who received health care services within one year of death were examined.

Methods: Of 157 decedents in the Worcester, Massachusetts, area between 2008 and 2012, 112 had contact with the health care system. Electronic medical records were reviewed for clinical characteristics, health service use, universal precautions, and substance use disorder management.

Buprenorphine-naloxone treatment responses differ between young adults with heroin and prescription opioid use disorders.

Background And Objectives: Opioid use disorder among young adults is rising sharply with an increase in morbidity and mortality. This study examined differences in treatment response to a fixed dose of buprenorphine-naloxone between heroin (HU) and prescriptions opioids (POU) users.

Methods: Eighty opioid dependent young adults (M = 22 years) were treated with buprenorphine-naloxone 16-4 mg/day for 8 weeks.

Increased Depression and Anxiety Symptoms are Associated with More Breakdowns in Cognitive Control to Cocaine Cues in Veterans with Cocaine Use Disorder.

Objective: Cue-elicited craving is a clinically important aspect of cocaine addiction directly linked to cognitive control breakdowns and relapse to cocaine-taking behavior. However, whether craving drives breakdowns in cognitive control toward cocaine cues in veterans, who experience significantly more co-occurring mood disorders, is unknown. The present study tests whether veterans have breakdowns in cognitive control because of cue-elicited craving or current anxiety or depression symptoms.

Arousal facilitates involuntary eye movements.

Attention plays a critical role in action selection. However, the role of attention in eye movements is complicated as these movements can be either voluntary or involuntary, with, in some circumstances (antisaccades), these two actions competing with each other for execution. But attending to the location of an impending eye movement is only one facet of attention that may play a role in eye movement selection.

Breakdowns of eye movement control toward smoking cues in young adult light smokers.

Background: Many studies suggest that dependent smokers have a preference or attentional bias toward smoking cues. The purpose of this study was to test the ability of infrequent non-dependent light smokers to control their eye movements by look away from smoking cues. Poor control in the lightest of smokers would suggest nicotine cue-elicited behavior occurring even prior to nicotine dependency as measured by daily smoking.

Cue-induced craving in patients with cocaine use disorder predicts cognitive control deficits toward cocaine cues.

Introduction: Cue-induced craving is a clinically important aspect of cocaine addiction influencing ongoing use and sobriety. However, little is known about the relationship between cue-induced craving and cognitive control toward cocaine cues. While studies suggest that cocaine users have an attentional bias toward cocaine cues, the present study extends this research by testing if cocaine use disorder patients (CDPs) can control their eye movements toward cocaine cues and whether their response varied by cue-induced craving intensity.

Reward, context, and human behaviour.

Animal models of reward processing have revealed an extensive network of brain areas that process different aspects of reward, from expectation and prediction to calculation of relative value. These results have been confirmed and extended in human neuroimaging to encompass secondary rewards more unique to humans, such as money. The majority of the extant literature covers the brain areas associated with rewards whilst neglecting analysis of the actual behaviours that these rewards generate.

Differential effects of reward and punishment on conscious and unconscious eye movements.

Very little is known about how human movements are influenced by abstract rewards and punishments relevant for human behaviour. The purpose of this study was to expand our knowledge of the behavioural effects of monetary reward and punishment. We introduced a high and low reward and punishment scheme into an antisaccade task where trials were either rewarded for a correct response (+1 or +25p) or punished for an incorrect response (-1 or -25p).

The automatic extraction and use of information from cues and go signals in an anti-saccade task.

In a gap antisaccade task that exogenously cues the side that subjects should antisaccade to, subjects find it hard to look away from the suddenly appearing go signal. Surprisingly, subjects are unaware of the majority of the prosaccade errors they make, and these errors remain unrecognised even when corrected by a second saccade requiring twice the amplitude [Fischer B, Weber H (1992) in Exp Brain Res 89:415-424]. This paper presents an extended antisaccade task that investigates what information, if any, subjects extract from redundant cues and go signals.

Differential effects of the Müller-Lyer illusion on reflexive and voluntary saccades.

Research has produced conflicting evidence as to whether saccade programming is or is not biased by perceptual illusions. However, previous studies have generally not distinguished between effects of illusory percepts on reflexive saccades, programmed automatically in response to an external visual signal, and voluntary saccades, programmed purposively to a location where no signal has occurred. Here we find that voluntary and reflexive saccades are differentially susceptible to the Müller-Lyer illusion; reflexive movements are reliably but modestly affected by the illusion, whereas voluntary movements show an effect similar to that of perceptual judgments.