Functional P2X Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia.

P2X receptors (P2XRs) are associated with numerous pathophysiological mechanisms, and this promotes them as therapeutic targets for certain neurodegenerative conditions. However, the identity of P2XR-expressing cells in the nervous system remains contentious. Here, we examined P2XR functionality in auditory nerve cells from rodents of either sex, and determined their functional and anatomic expression pattern.