Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation.

The surveillance of translation is critical for the fitness of organisms from bacteria to humans. Ribosome-associated Quality Control (RQC) is a surveillance mechanism that promotes the elimination of truncated polypeptides, byproducts of ribosome stalling during translation. In canonical mammalian RQC, NEMF binds to the large ribosomal subunit and recruits the E3 ubiquitin ligase Listerin, which marks the nascent-chains for proteasomal degradation.

Clinically relevant mouse models of severe spinal muscular atrophy with respiratory distress type 1.

Spinal Muscular Atrophy with Respiratory Distress (SMARD1) is a lethal infantile disease, characterized by the loss of motor neurons leading to muscular atrophy, diaphragmatic paralysis, and weakness in the trunk and limbs. Mutations in IGHMBP2, a ubiquitously expressed DNA/RNA helicase, have been shown to cause a wide spectrum of motor neuron disease. Though mutations in IGHMBP2 are mostly associated with SMARD1, milder alleles cause the axonal neuropathy, Charcot-Marie-Tooth disease type 2S (CMT2S), and some null alleles are potentially a risk factor for sudden infant death syndrome (SIDS).

Dynamic retrieval of events and associations from memory: An integrated account of item and associative recognition.

Memory theories distinguish between item and associative information, which are engaged by different tasks: item recognition uses item information to decide whether an event occurred in a particular context; associative recognition uses associative information to decide whether two events occurred together. Associative recognition is slower and less accurate than item recognition, suggesting that item and associative information may be represented in different forms and retrieved using different processes. Instead, I show how a dynamic model (Cox & Criss, 2020; Cox & Shiffrin, 2017) accounts for accuracy and response time distributions in both item and associative recognition with the same set of representations and processes.

The Effect of Cannabidiol on Subjective Responses to Endurance Exercise: A Randomised Controlled Trial.

Background: Exercise is known to improve health. However, it can be unpleasant, often inducing negative feelings, or 'affect'. Cannabidiol (CBD), a non-intoxicating constituent of the cannabis plant, has been reported to enhance the subjective experience of exercise; specifically, in trained individuals performing fixed-intensity endurance activity.

Day-to-Day Glycemic Variability Using Continuous Glucose Monitors in Endurance Athletes.

Objectives: The application of continuous glucose monitors (CGMs) to measure interstitial glucose in athletic populations is limited by the lack of accepted athlete-specific reference values. The aim of this study was to develop athlete-specific reference ranges for glycemic variability under standardized diet and exercise conditions.

Methods: A total of 12 elite racewalkers (n = 7 men, 22.

No position-specific interference from prior lists in cued recognition: A challenge for position coding (and other) theories of serial memory.

Position-specific intrusions of items from prior lists are rare but important phenomena that distinguish broad classes of theory in serial memory. They are uniquely predicted by position coding theories, which assume items on all lists are associated with the same set of codes representing their positions. Activating a position code activates items associated with it in current and prior lists in proportion to their distance from the activated position.

Against naïve induction from experimental data.

This commentary argues against the indictment of current experimental practices such as piecemeal testing, and the proposed integrated experiment design (IED) approach, which we see as yet another attempt at automating scientific thinking. We identify a number of undesirable features of IED that lead us to believe that its broad application will hinder scientific progress.

The impact of moulage on learners' experience in simulation-based education and training: systematic review.

Background: Moulage is a technique used to simulate injury, disease, aging and other physical characteristics specific to a scenario, often used in health and emergency worker training, predominantly for simulation-based learning activities. Its use in allied health fields is unclear. Previous work has explored moulage as an adjunct for authentic simulations, however there is opportunity for broadening its scope.

Fluid intake is a strong predictor of outdoor team sport pre-season training performance.

Our aim was to characterize fluid intake during outdoor team sport training and use generalized additive models to quantify interactions with the environment and performance. Fluid intake, body mass (BM) and internal/external training load data were recorded for male rugby union ( = 19) and soccer ( = 19) athletes before/after field training sessions throughout an 11-week preseason (357 observations). Running performance (GPS) and environmental conditions were recorded each session and generalized additive models were applied in the analysis of data.

Serial order depends on item-dependent and item-independent contexts.

We address four issues in response to Osth and Hurlstone's (2022) commentary on the context retrieval and updating (CRU) theory of serial order (Logan, 2021). First, we clarify the relations between CRU, chains, and associations. We show that CRU is not equivalent to a chaining theory and uses similarity rather than association to retrieve contexts.

The Use of Continuous Glucose Monitors in Sport: Possible Applications and Considerations.

This review discusses the potential value of tracking interstitial glucose with continuous glucose monitors (CGMs) in athletes, highlighting possible applications and important considerations in the collection and interpretation of interstitial glucose data. CGMs are sensors that provide real time, longitudinal tracking of interstitial glucose with a range of commercial monitors currently available. Recent advancements in CGM technology have led to the development of athlete-specific devices targeting glucose monitoring in sport.

The Impact of a 'Remotely-Delivered' Sports Nutrition Education Program on Dietary Intake and Nutrition Knowledge of Junior Elite Triathletes.

Triathlon is a physically demanding sport, requiring athletes to make informed decisions regarding their daily food and fluid intake to align with daily training. With an increase in uptake for online learning, remotely delivered education programs offer an opportunity to improve nutritional knowledge and subsequent dietary intake in athletes. This single-arm observational study aimed to evaluate the effectiveness of a remotely delivered nutrition education program on sports nutrition knowledge and the dietary intake of junior elite triathletes (n = 21; female n = 9; male n = 12; 18.

Clinically relevant mouse models of Charcot-Marie-Tooth type 2S.

Charcot-Marie-Tooth disease is an inherited peripheral neuropathy that is clinically and genetically heterogenous. Mutations in IGHMBP2, a ubiquitously expressed DNA/RNA helicase, have been shown to cause the infantile motor neuron disease spinal muscular atrophy with respiratory distress type 1 (SMARD1), and, more recently, juvenile-onset Charcot-Marie-Tooth disease type 2S (CMT2S). Using CRISPR-cas9 mutagenesis, we developed the first mouse models of CMT2S [p.

Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease.

Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although most cases of ALS are sporadic, 5-10% of cases are familial, with mutations associated with over 40 genes. There is variation of ALS symptoms within families carrying the same mutation; the disease may develop in one sibling and not in another despite the presence of the mutation in both.

Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.

In this study we investigated the effects of variously derived sources of low-dose caffeine on mood/arousal and cognitive performance. Twenty-two participants (15 men, 7 women; age: 28.2, 9.

Forecasting the rate of hand injuries in Singapore.

Purpose: This study aims to analyse the correlation between the incidence rate of hand injuries and various major economic indicators in Singapore. We hypothesise that the number of hand injuries is correlated to activity in the construction and manufacturing industries in Singapore.

Methods: Twenty thousand seven hundred sixty-four patients who underwent hand surgeries in a tertiary institution between 2012 to 2018 were reviewed.

Salience by competitive and recurrent interactions: Bridging neural spiking and computation in visual attention.

Decisions about where to move the eyes depend on neurons in frontal eye field (FEF). Movement neurons in FEF accumulate salience evidence derived from FEF visual neurons to select the location of a saccade target among distractors. How visual neurons achieve this salience representation is unknown.

Sports Dietitian practices for assessing and managing athletes at risk of low energy availability (LEA).

Objectives: To characterise the assessment and management practices employed by Sports Dietitians when assessing and managing athletes at risk of low energy availability (LEA).

Design: 55 Sports Dietitians participated in an online questionnaire that captured the typical methods used to identify and manage LEA in athletic populations.

Methods: The questionnaire consisted of 27 questions which explored common methods used to identify and manage LEA, as well as dietary methods employed and barriers experienced by Sports Dietitians.

Effect of Acetaminophen on Endurance Cycling Performance in Trained Triathletes in Hot and Humid Conditions.

Purpose: The effect of acetaminophen (ACT, also known as paracetamol) on endurance performance in hot and humid conditions has been shown previously in recreationally active populations. The aim of this study was to determine the effect of ACT on physiological and perceptual variables during steady-state and time-trial cycling performance of trained triathletes in hot and humid conditions.

Methods: In a randomized, double-blind crossover design, 11 triathletes completed ∼60 minutes steady-state cycling at 63% peak power output followed by a time trial (7 kJ·kg body mass-1, ∼30 min) in hot and humid conditions (∼30°C, ∼69% relative humidity) 60 minutes after consuming either 20 mg·kg body mass-1 ACT or a color-matched placebo.

Free-Living Dietary Intake in Tactical Personnel and Implications for Nutrition Practice: A Systematic Review.

Tactical personnel (including military, law enforcement, and fire and rescue) are responsible for ensuring national and public safety. Dietary intake is an important consideration to support optimal health and performance. The aims of this systematic review were to: (1) describe the reported free-living dietary intake (energy and macronutrients) of tactical personnel, and (2) describe the practical implications of reported dietary intakes to support the physical and dietary requirements of tactical personnel.

Serial memory: Putting chains and position codes in context.

From the beginning of research on serial memory, chaining theories and position coding theories have been pitted against each other. The central question is whether items are associated with each other or with a set of position codes that are independent of the items. Around the turn of this century, the debate focused on serial recall tasks and patterns of error data that chaining models could not accommodate.