Population pharmacokinetics of ticarcillin in critically ill patients receiving extended daily diafiltration.

The aim of this study was to describe the population pharmacokinetics of ticarcillin during extended daily diafiltration (EDDf) in critically ill patients with acute kidney injury. Blood samples were collected from critically ill patients prescribed ticarcillin during one to two dosing intervals during which EDDf was performed. Plasma samples were measured using a validated ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method.

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Haemodynamic stability is maintained during extended daily diafiltration in critically ill septic patients.

Background: Extended daily diafiltration (EDDf) is a prolonged intermittent dialysis technique introduced as an alternative to continuous renal replacement therapy in critically ill patients. Although EDDf has the advantages of ease of use, low cost and patient tolerability, there is concern that the high blood and dialysate flow rates used with EDDf may precipitate haemodynamic instability.

Objective: To identify whether haemodynamic changes occur during the course of EDDf therapy in adult patients who are admitted to the intensive care unit with sepsis and require dialysis.