Impact of Treatment of Pudendal Neuralgia on Pain: A Systematic Review and Meta-Analysis.

Introduction And Hypothesis: Pudendal neuralgia is chronic pelvic pain associated with the pudendal nerve. Unfortunately, the best treatment approach is unknown. Our objective was to systematically assess interventions for pudendal neuralgia for improvement in pain.

Pd-Catalyzed Heteroannulation Using -Arylureas as a Sterically Undemanding Ligand Platform.

We report the development of ureas as sterically undemanding pro-ligands for Pd catalysis. -Arylureas outperform phosphine ligands for the Pd-catalyzed heteroannulation of -tosyl--bromoanilines and 1,3-dienes, engaging diverse coupling partners for the preparation of 2-subsituted indolines, including sterically demanding substrates that have not previously been tolerated. Experimental and computational studies on model Pd-urea and Pd-ureate complexes are consistent with monodentate binding through the nonsubstituted nitrogen, which is uncommon for metal-ureate complexes.