Publications by authors named "Gregorius P M Mannes"
Article Synopsis
- Palovarotene is an oral retinoid agonist that showed promising results in animal models for treating emphysema by reducing inflammation and aiding repair.
- A study called REPAIR tested palovarotene's safety and effectiveness over one year on 262 patients with severe α(1)-antitrypsin deficiency and emphysema, comparing it to a placebo.
- Results indicated that, although palovarotene was well tolerated, it did not provide significant benefits in improving lung density or functional outcomes compared to the placebo group.
