Publications by authors named "Gregoria Megias-Lobon"
Background: Fluconazole-resistant Candida parapsilosis (FRCP) is a matter of concern in Spain.
Objectives: We here report a FRCP spread across a 777-bed referral hospital located in Burgos, Spain, during the COVID-19 pandemic.
Patients/methods: In April 2021, an FRCP isolate (MIC = 64 mg/L, E-test®) from a hospitalised patient was detected.
Article Synopsis
- Candidemia, often linked to medical implants, has seen rising cases of fluconazole-resistant strains in Spain, particularly during the COVID-19 pandemic.
- A study analyzed 1,315 yeast isolates from 2000 to 2021, revealing increased instances of acquired resistance to fluconazole and voriconazole in various Spanish hospitals.
- Three prevalent clones were identified, with a need for further research to understand their expansion and genetic connections.
Introduction: A growing evidence suggests that immune dysregulation and thrombotic phenomena are key features in the pathophysiology of COVID-19. Apart from antivirals and respiratory support, anticoagulants, corticoids and immunomodulators are increasingly being prescribed, especially for more severe cases. We describe the clinical outcome of a large cohort of patients preferentially treated with glucocorticoids and interleukin inhibitors.
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