A randomized crossover trial of IV fluid replacement versus no fluid replacement in autologous blood donors with cardiovascular disease.

Background: The aim of this study was to compare the incidence of arterial hypotension in response to autologous blood donation with and without simultaneous IV fluid replacement in 60 patients with cardiovascular disease.

Study Design And Methods: Each patient donated two 500 mL units of blood at an interval of 7 days. Following random allocation within a two-stage crossover design, either the first or second unit was collected with a simultaneous IV infusion of 500 mL of HES.