Publications by authors named "Gregoire Le Meur"
Lancet Digit Health
May 2024
Article Synopsis
- Acute leukaemias are serious blood cancers that require quick and accurate diagnosis of their three main types (ALL, AML, APL) to ensure proper treatment and reduce mortality risk, but expert diagnosis can be challenging due to resource limitations.
- Researchers aimed to develop a machine-learning model using routine laboratory data to identify leukaemia subtypes and improve diagnostic accuracy without the need for extensive cytological expertise.
- The study involved data from six French hospitals and successfully built the Artificial Intelligence Prediction of Acute Leukemia (AI-PAL) tool, which demonstrated strong performance in predicting leukaemia subtypes based on 19 selected laboratory parameters from the patient datasets.
Transplant Cell Ther
January 2023
Article Synopsis
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) using FLAMSA-Bu is a treatment option for high-risk acute myeloid leukemia (AML) patients, particularly those who are refractory or have relapsed.
- A study of 165 patients showed that detectable minimal residual disease (MRD) before transplantation was linked to worse overall survival (OS) and higher relapse rates following the procedure.
- The findings highlight that pre-transplant MRD status is a crucial indicator of patient outcomes, with MRD negativity correlated to better survival and reduced relapse risk, while factors such as age and risk stratification did not significantly impact outcomes.
