Cost-effectiveness of infant hypoallergenic formulas to manage cow's milk protein allergy in France.

Background: Clinician's choice of hypoallergenic formulas in the first-line management of cow's milk protein allergy (CMPA) should be informed by evidence on clinical efficacy and cost-effectiveness.

Objective: We compare the cost-effectiveness of amino acid-based formula (AAF), extensively hydrolyzed casein formula with Lactobacillus rhamnosus Gorbach Goldin (EHCF+LGG), extensively hydrolyzed whey formula (EHWF), and rice hydrolyzed formula (RHF) in non-breastfed children in France.

Methods: Immunotolerance and atopic manifestations' prevalence were based on a prospective non-randomized study with a 36-month follow-up.

[Diagnosis and treatment of VRS].

Acute bronchiolitis is a very common condition in infants. It has a major effect on consultations in cities and use of hospital emergency rooms. The analysis of clinical data makes it easily to confirm the diagnosis and to assess the severity at the time of the evaluation, which determines the rest of the treatment.

Saliva for molecular detection of SARS-CoV-2 in pre-school and school-age children.

SARS-CoV-2 diagnosis is a cornerstone for the management of coronavirus disease 2019 (COVID-19). Numerous studies have assessed saliva performance over nasopharyngeal sampling (NPS), but data in young children are still rare. We explored saliva performance for SARS-CoV-2 detection by RT-PCR according to the time interval from initial symptoms or patient serological status.

Perception of medical education by learners and teachers during the COVID-19 pandemic: a cross-sectional survey of online teaching.

COVID-19 lockdowns have deeply impacted teaching programs. Online teaching has suddenly become the main form of medical education, a form that may be used as long as the pandemic continues. We aimed at analyzing how online teaching was perceived by both teachers and learners to help determine how to adapt curricula in the next few years.

Consensus statements on the information to deliver after a febrile seizure.

Febrile seizures (FS) are usually self-limiting and cause no morbidity. Nevertheless they represent very traumatic events for families. There is a need to identify key messages that reassure carers and help to prevent inappropriate, anxiety-driven behaviors associated with "fever phobia.

Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020.

BackgroundChildren have a low rate of COVID-19 and secondary severe multisystem inflammatory syndrome (MIS) but present a high prevalence of symptomatic seasonal coronavirus infections.AimWe tested if prior infections by seasonal coronaviruses (HCoV) NL63, HKU1, 229E or OC43 as assessed by serology, provide cross-protective immunity against SARS-CoV-2 infection.MethodsWe set a cross-sectional observational multicentric study in pauci- or asymptomatic children hospitalised in Paris during the first wave for reasons other than COVID (hospitalised children (HOS), n = 739) plus children presenting with MIS (n = 36).

Five-year outcome of children with idiopathic nephrotic syndrome: the NEPHROVIR population-based cohort study.

Background: The optimal therapeutic regimen for children at onset of idiopathic nephrotic syndrome (INS) is still under debate. A better knowledge of the disease's course is necessary to design more appropriate and/or personalized treatment protocols.

Methods: We report the 5-year outcome of patients included from December 2007 to May 2010 in the prospective multicentric and multiethnic population-based NEPHROVIR study.

Skeletal evolution in Marfan syndrome: growth curves from a French national cohort.

BackgroundTo describe the growth patterns of children affected by Marfan syndrome (MFS) compared with those of unaffected children and to create growth charts.MethodsAn observational study of children referred to the French National MFS Reference Centre. A total of 259 children carrying an FBN1 gene mutation and fulfilling Ghent 1 criteria (MFS group) and 474 mutation-negative sibling controls (non-MFS group) were evaluated.

Sleep duration, quality of life and depression in adolescents: a school-based survey.

Background: The main objective of this study was to assess the link between sleep duration, quality of life and depression in adolescents. The secondary objective was to study the sleeping behavior of a large sample of adolescents from different socioeconomic backgrounds.

Methods: Study subjects were high school students studying in or around Paris with a general, vocational or technological training background.

[Signs of severity of acute bronchiolitis of the infant].

Signs of severity of acute bronchiolitis in the infant. About 3% of infants suffering from bronchiolitis will need hospitalization. Criteria to decide are mainly clinical: comorbidities (prematurity, cardiopulmonary pathology, age less than 6 weeks old), intensity of respiratory distress attested by polypnea, toxic aspect, inadequate oral food intake, need for O2 or and socio-familial criteria for confidence in looking for the child.

[Food protein-induced enterocolitis syndrome].

A little known pathology, increasingly diagnosed. Late vomiting after food intake predominate. An insidious chronic form, an explosive acute form.

[Managing the risks of accident in child with food allergy].

Managing the risks of accident in child with food allergy. Prevention of accidents in children with food allergy requires above all an elimination diet of the allergen(s). The family can be able to identify allergens by reading labels or be informed of composition by restaurants.

[Emergency management of food reaction in a child].

Emergency management of food reaction in a child. Emergency management of food anaphylaxis depends on severity of the signs. In case of minor signs, antihistamines may be sufficient to contain the allergic reaction.

Risk of Readmission for Wheezing during Infancy in Children with Congenital Diaphragmatic Hernia.

Rationale: Congenital diaphragmatic hernia (CDH) is associated with a high incidence of respiratory problems, even after initial hospital discharge. These problems are likely to lead to re-hospitalization during infancy, although actual frequency of readmissions is unknown.

Objective: We aimed to determine the rate of hospitalization for wheezing in infants with CDH between the time of initial discharge and 24 months of age, and to identify factors associated with readmission.

Study of phenotype evolution during childhood in Marfan syndrome to improve clinical recognition.

Purpose: Because diagnosis of Marfan syndrome is difficult during infancy, we used a large cohort of children to describe the evolution of the Marfan syndrome phenotype with age.

Methods: Two hundred and fifty-nine children carrying an FBN1 gene mutation and fulfilling Ghent criteria were compared with 474 non-Marfan syndrome children.

Results: Prevalence of skeletal features changed with aging: prevalence of pectus deformity increased from 43% at 0-6 years to 62% at 15-17 years, wrist signs increased from 28 to 67%, and scoliosis increased from 16 to 59%.

Posterior reversible encephalopathy syndrome revealing renal artery stenosis in a child.

A 14-year-old girl was admitted to the emergency department for repeated seizures with no fever. High blood pressure at admission was ascribed to the status epilepticus. Seizure recurrence promoted transfer to the paediatric intensive care unit.

[Clinical exam of children from 3 to 12 years].

The specific aims of clinical exams of children from 3 to 12 years of age are to assess: growth including weight and height, and body mass index (BMI) to prevent obesity, neurodevelopment both motor and intellectual including sensorial impairment to detect early learning disabilities, immunization adequacy by assessing routine schedule of vaccination and booster. The GP or paediatrician should cooperate with specialised services and nursery or primary schools to match the system of education to the needs of a given child, particularly in case of learning disabilities (normally, entry into kindergarden at 6 years of age).