Publications by authors named "Gregg Goldschlager"
Despite the increasing use of rabbits as companion animals and models for biomedical research, rabbits have not been extensively studied to identify an efficacious postsurgical analgesic that does not cause systemic complications. The synergy of NSAID and systemic opioids is well-documented, and their combined use reduces the amount of either drug required for adequate analgesia. We measured fecal corticosterone metabolites (FCM) in rabbits after a minimally invasive vascular cut-down procedure.
View Article and Find Full Text PDFPurpose: To investigate the short-term reproducibility of black-blood dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in atherosclerotic rabbits to evaluate the potential of this technique to be a reliable readout of plaque progression and/or regression upon therapeutic intervention.
Materials And Methods: Atherosclerotic rabbits were imaged at baseline and 24 hours later with DCE-MRI on a 1.5T MRI system.
Article Synopsis
- The study aimed to assess two noninvasive imaging techniques, black blood dynamic contrast enhanced MRI (DCE-MRI) and 18-fluorine-fluorodeoxyglucose (18F-FDG) PET, for detecting inflammation in atherosclerosis using a rabbit model.
- Atherosclerotic plaques were created in rabbits through endothelial abrasions and a high-fat diet, with imaging performed to evaluate neovessel content in the plaques.
- Results showed a significant correlation between neovessel count and imaging parameters from both DCE-MRI and 18F-FDG PET, suggesting these methods could be useful in clinical settings for evaluating and monitoring atherosclerosis.