Analysis of the fecal metagenome in long-term survivors of pancreas cancer.

Background: The 5-year overall survival of pancreas adenocarcinoma (PCa) remains less than 10%. Clinical and tumor genomic characteristics have not differentiated PCa long-term survivors (LTSs) from unselected patients. Preclinical studies using fecal transplant experiments from LTSs of PCa have revealed delayed tumor growth through unknown mechanisms involving the fecal microbiota.

Robotic approach mitigates the effect of major complications on survival after pancreaticoduodenectomy for periampullary cancer.

Background: Major complications (MCs) after pancreaticoduodenectomy (PD) are a known independent predictor of worse oncologic outcomes. There are limited data on the effect of major complications on long-term outcomes after robotic PD (RPD). The aim of this study is to compare the effect of MC on overall (OS) and disease-free survival (DFS) after RPD and open PD (OPD).

Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice.

Major depressive disorder (MDD) is a severe disease of unknown pathogenesis that will affect ∼10% of people during their lifetime. Therapy for MDD requires prolonged treatment and often fails, predicating a need for novel treatment strategies. Here, we report increased ceramide levels in the blood plasma of MDD patients and in murine stress-induced models of MDD.

The volume-outcomes relationship in donation after circulatory death liver transplantation.

Background: Donation after circulatory death (DCD) liver transplantation (LT) has become an effective mechanism for expanding the donor pool and decreasing waitlist mortality. However, it is unclear if low-volume DCD centers can achieve comparable outcomes to high-volume centers.

Methods: From 2011 to 2019 utilizing the United Network for Organ Sharing (UNOS) database, liver transplant centers were categorized into tertiles based on their annual volume of DCD LTs.

Ten quick tips for making things findable.

The distribution of scholarly content today happens in the context of an immense deluge of information found on the internet. As a result, researchers face serious challenges when archiving and finding information that relates to their work. Library science principles provide a framework for navigating information ecosystems in order to help researchers improve findability of their professional output.

Ten quick tips for delivering programming lessons.

Teaching well is a craft like any other, and success often comes from an accumulation of small improvements rather than from any single large change. This paper describes 10 practices you can use when teaching programming (and other subjects). All are easy to adopt and have proven their value in institutional classrooms, intensive workshops, and other settings.

Managing Genetic Diversity and Extinction Risk for a Rare Plains Bison (Bison bison bison) Population.

Unfenced plains bison are rare and only occur in a small number of locations throughout Canada and the United States. We examined management guidelines for maintenance of genetic health and population persistence for a small and isolated population of plains bison that occupy the interface between a protected national park and private agricultural lands. To address genetic health concerns, we measured genetic diversity relative to other populations and assessed the potential effects of genetic augmentation.

Ten quick tips for creating an effective lesson.

We present 10 tips for building effective lessons that are grounded in empirical research on pedagogy and cognitive psychology and that we have found to be practically useful in both classroom and free-range settings.

Investing in Gulfport: Development of an Academic-Community Partnership to Address Health Disparities.

Background: Invest Health, a collaboration between the Robert Wood Johnson Foundation and The Reinvestment Fund, selected 50 midsized cities to participate in a health initiative that encourages cross-sector alliances to think creatively about mechanisms that address barriers to reducing health disparities among low-income populations. Gulfport, Mississippi, was 1 of 50 teams chosen to participate.

Objective: To develop an academic-community partnership among the University of Southern Mississippi, Coastal Family Health Center (CFHC), Mercy Housing and Human Development (MHHD), the Mississippi State Department of Health Office of Health Disparity Elimination, and Gulfport residents to create the Healthy Gulfport Initiative, and, ultimately, the Gulf Coast Healthy Communities Collaborative (GCHCC).

Getting HIV Self-Test Kits into the Home for Young African American MSM in Los Angeles: A Qualitative Report.

Expanded access to HIV self-testing has the potential to increase the number of young adult African American men who have sex with men (MSM) who are regularly aware of their HIV status (Krause, Subklew-Sehume, Kenyon, & Colebunders, 2013; Marlin et al., 2014). Because African American MSM communities have the highest HIV risk rate of all risk groups, regular testing behaviors are essential for HIV prevention (McNairy & El-Sadr, 2014; Young et al.

Good enough practices in scientific computing.

Computers are now essential in all branches of science, but most researchers are never taught the equivalent of basic lab skills for research computing. As a result, data can get lost, analyses can take much longer than necessary, and researchers are limited in how effectively they can work with software and data. Computing workflows need to follow the same practices as lab projects and notebooks, with organized data, documented steps, and the project structured for reproducibility, but researchers new to computing often don't know where to start.

Ten simple rules for making research software more robust.

Software produced for research, published and otherwise, suffers from a number of common problems that make it difficult or impossible to run outside the original institution or even off the primary developer's computer. We present ten simple rules to make such software robust enough to be run by anyone, anywhere, and thereby delight your users and collaborators.

HIV Testing Preferences Among MSM Members of an LGBT Community Organization in Los Angeles.

Lack of regular HIV testing puts African American, Asian, and Latino men who have sex with men (MSM) at high risk for HIV infection. Rapid self-testing may be an effective option for these men. We explored acceptability, preferences, and usability of HIV self-test kits with MSM of color using semi-structured focus groups to discuss HIV testing history, reasons for testing, and self-testing preferences.

Increased fetal lung T2 signal is not due to increasing surfactant concentration: an in vitro T2 mapping analysis.

Object: The aim of this study was to perform in vitro T2 mapping of serial dilutions of pharmaceutical surfactant.

Materials And Methods: Magnetic resonance imaging. Magnetic resonance scanning was performed on serial dilutions of surfactant on large bore clinical magnets at a field strength of 1.

Extravascular lung water and pulmonary vascular permeability index as markers predictive of postoperative acute respiratory distress syndrome: a prospective cohort investigation.

Objective: Robust markers of subclinical perioperative lung injury are lacking. Extravascular lung water indexed to predicted body weight and pulmonary vascular permeability index are two promising early markers of lung edema. We aimed to evaluate whether extravascular lung water indexed to predicted body weight and pulmonary vascular permeability index would identify patients at risk for clinically significant postoperative pulmonary edema, particularly resulting from the acute respiratory distress syndrome.