Publications by authors named "Greg S Spradlin"
Purpose: To investigate the effect of variable dose rate on biologically effective dose (BED).
Materials And Methods: By using the linear-quadratic (LQ) model with bi-exponential repair, we analytically determine the time-dependent dose rate [Formula: see text] which minimizes the effective protraction factor (Geff) and BED under the condition of fixed fraction time and dose per fraction. Because normal tissue complication probability (NTCP) monotonically decreases with decreasing BED, the dose rate [Formula: see text] also minimizes NTCP.