Adolescent substance use disorder during the early stages of bipolar disorder: a prospective high-risk study.

Background: There is a paucity of longitudinal data characterizing the relationship between substance use disorder (SUD) and the early clinical course of bipolar disorder (BD). We studied this relationship in a prospectively assessed cohort of high-risk offspring.

Methods: Eligible families had one parent with confirmed BD based on SADS-L interviews and best estimate diagnostic procedure.