Publications by authors named "Greg C Rogers"
Article Synopsis
- This study focuses on understanding how prostate cancer transitions from a non-aggressive state to an invasive one, which could improve treatment strategies for patients.
- Researchers discovered a new signaling pathway connecting low oxygen levels (hypoxia) and the PIM1 kinase to the actin cytoskeleton, crucial for cell movement.
- They found that when PIM1 modifies a protein called ABI2, it boosts cell movement and tumor invasion in prostate cancer, indicating that targeting PIM1 could be a potential therapeutic approach.
The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein. Geminin depletion or overexpression of Cdt1 or Cdc6 in human cells causes rereplication, a form of endogenous DNA damage.
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