Return to sports bridge program improves outcomes, decreases ipsilateral knee re-injury and contralateral knee injury rates post-ACL reconstruction.

Purpose: To present the results of a return to sports bridge program designed to reduce knee injuries following ACL reconstruction and physical therapy.

Methods: One hundred and fifty (male = 83, female = 67) patients participated in a whole body neuromuscular control, progressive resistance strength and agility training program. Post-program testing included functional movement form, dynamic knee stability, lower extremity power, agility, and sports skill assessments.

Mathematical Details on a Cancer Resistance Model.

One of the most important factors limiting the success of chemotherapy in cancer treatment is the phenomenon of drug resistance. We have recently introduced a framework for quantifying the effects of induced and non-induced resistance to cancer chemotherapy (Greene et al., 2018a, 2019).

Major Depressive Disorder Is Associated With Differential Expression of Innate Immune and Neutrophil-Related Gene Networks in Peripheral Blood: A Quantitative Review of Whole-Genome Transcriptional Data From Case-Control Studies.

Background: Whole-genome transcription has been measured in peripheral blood samples as a candidate biomarker of inflammation associated with major depressive disorder.

Methods: We searched for all case-control studies on major depressive disorder that reported microarray or RNA sequencing measurements on whole blood or peripheral blood mononuclear cells. Primary datasets were reanalyzed, when openly accessible, to estimate case-control differences and to evaluate the functional roles of differentially expressed gene lists by technically harmonized methods.

Prostate cancer-derived holoclones: a novel and effective model for evaluating cancer stemness.

Prostate cancer accounts for approximately 13.5% of all newly diagnosed male cancer cases. Significant clinical burdens remain in terms of ineffective prognostication, with overtreatment of insignificant disease.

Advances in facial nerve management in the head and neck cancer patient.

Purpose Of Review: The purpose of this review is to summarize best practices in facial nerve management for patients with head and neck cancer. In addition, we provide a review of recent literature on novel innovations and techniques in facial reanimation surgery.

Recent Findings: Although recommended when tumor ablation surgery requires facial nerve sacrifice, facial reanimation procedures are not always performed.

Mechanisms of Soybean Host-Plant Resistance Against Megacopta cribraria (Hemiptera: Plataspidae).

A number of soybean varieties traditionally bred for resistance to various soybean arthropod pests have been identified as resistant to Megacopta cribraria (F.) (Hemiptera: Plataspidae). However, the mechanisms of host-plant resistance (HPR) in this system are not understood.

Psychological foundations of emerging technologies for teaching and learning in higher education.

As the research on the use of educational technologies increases, greater focus is being placed on the psychological processes underlying teaching and learning with these tools. In this research review, we examine six contemporary technologies identified in the 2020 edition of the Horizon Report through the lens of educational psychology theory. Specifically, we highlight the educational, cognitive, and social psychological processes that unfold during teaching and learning with each technology and illustrate how considering these processes can inform study and use of educational technologies and subsequent learning outcomes.

A medical student scholarly concentrations program: scholarly self-efficacy and impact on future research activities.

Background: The Scholarly Concentrations program was established at Johns Hopkins University School of Medicine in 2009 with the aim of instilling passion for scholarship.

Objective: Our study aimed to determine whether the Scholarly Concentrations program achieves positive changes in medical student self-efficacy in conducting research and, if so, whether this results in future career aspirations toward scholarship.

Design: We used the Clinical Research Appraisal Inventory-Short Form (CRAI-SF) to assess changes in self-efficacy among students completing the Scholarly Concentrations program between 2014 and 2017.

Cotton thrips infestation predictor: a practical tool for predicting tobacco thrips (Frankliniella fusca) infestation of cotton seedlings in the south-eastern United States.

Background: Thrips (order Thysanoptera) infestations of cotton seedlings result in plant injury, increasing the detrimental consequences of other challenges to production agriculture, such as abiotic stress or infestation by other pests. Using Frankliniella fusca as a thrips species of focus, we empirically developed a composite model of thrips phenology and cotton seedling susceptibility to predict site-specific infestation risk so that monitoring and other resources can be allocated efficiently, to optimize the timing of thrips control measures to maximize effectiveness, and to inform stakeholders about the dynamics of thrips infestation and cotton seedling injury at a time when thrips are evolving resistance to commonly-used pesticides.

Results: A mixture distribution model of thrips infestation potential, fit to data describing F.

Resistance monitoring to four insecticides and mechanisms of resistance in Lygus lineolaris Palisot de Beauvois (Hemiptera: Miridae) populations of southeastern USA cotton.

Background: Economically damaging infestations of the tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), have become more frequent in Virginia and North Carolina cotton since 2013 and 2010, respectively. Foliar insecticide use has increased dramatically in response. Efficacy data (LC ) are needed to evaluate L.

The Impact of Infection and Inflammation on Drug Metabolism, Active Transport, and Systemic Drug Concentrations in Veterinary Species.

Within human medicine, it is recognized that the pharmacokinetics (PK) of many compounds can be altered by the presence of inflammation or infection. Research into the reason for these changes has identified pathways that can influence drug absorption, clearance, and tissue distribution. In contrast, far less is known about these relationships within the framework of veterinary medicine.

Location of (Lepidoptera: Noctuidae) larvae on different plant parts of determinate and indeterminate soybean.

Helicoverpa zea (Boddie) is a damaging pest of many crops including soybean, Glycine max (L.), especially in the southern United States. Previous studies have concluded that oviposition and development of H.

Synthesis and crystal structure of (2,4a,8a)-6-oxo-2,4a,6,8a-tetra-hydro-pyrano[3,2-]pyran-2-carboxamide.

The pyran-opyran amide (2,4a,8a)-6-oxo-2,4a,6,8a-tetra-hydro-pyrano[3,2-]pyran-2-carboxamide, CHNO, , was prepared by a chemoselective hydration of the corresponding nitrile, , using a heterogeneous catalytic method based on copper(II) supported on mol-ecular sieves, in the presence of acetaldoxime. Compound belongs to a new class of pyran-opyrans that possess anti-bacterial and phytotoxic activity. Crystallographic analysis of shows a bent structure for the -fused bicyclic pyran-opyran, similar to nitrile .

Changes in Nasal Colonization and Infection Rates After Nasal Surgery.

The relationship between nasal flora and infection rates in patients undergoing nasal surgery is of interest. This relationship has been studied though changes that may take place due to surgery have never been elucidated. To assess colonization rates and changes in colonization patterns of methicillin-resistant or methicillin-sensitive (MRSA/MSSA) in nasal flora in patients undergoing nasal surgery and to determine whether colonization is a risk factor for postoperative infection.

Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer.

The alarming situation of the 2019 novel coronavirus disease (COVID‐19) is contrasted by the limited efforts to curb the spread and impact of the disease among patients with cancer. This commentary proposes a simple 5‐part strategy plus rapidly expanded use of telemedicine to anticipate and deal with COVID‐19 and, by extension, future epidemics in patients with cancer.

Prospective, randomized, single-blinded, multi-center phase II trial of two HER2 peptide vaccines, GP2 and AE37, in breast cancer patients to prevent recurrence.

Purpose: AE37 and GP2 are HER2 derived peptide vaccines. AE37 primarily elicits a CD4+ response while GP2 elicits a CD8+ response against the HER2 antigen. These peptides were tested in a large randomized trial to assess their ability to prevent recurrence in HER2 expressing breast cancer patients.

Two Ways to Build a Thought: Distinct Forms of Compositional Semantic Representation across Brain Regions.

To understand a simple sentence such as "the woman chased the dog", the human mind must dynamically organize the relevant concepts to represent who did what to whom. This structured recombination of concepts (woman, dog, chased) enables the representation of novel events, and is thus a central feature of intelligence. Here, we use functional magnetic resonance (fMRI) and encoding models to delineate the contributions of three brain regions to the representation of relational combinations.

Predicting pediatric tracheal airway size from anthropomorphic measurements.

Objectives: To determine the relationship between body mass index and tracheal airway size in children.

Methods: Retrospective case series. CT or MRI images of the neck of 171 pediatric patients obtained from 2000 to 2010 at a tertiary pediatric hospital were analyzed.