Adiabatic Evolution of Low-Temperature Many-Body Systems.

We consider finite-range, many-body fermionic lattice models and we study the evolution of their thermal equilibrium state after introducing a weak and slowly varying time-dependent perturbation. Under suitable assumptions on the external driving, we derive a representation for the average of the evolution of local observables via a convergent expansion in the perturbation, for small enough temperatures. Convergence holds for a range of parameters that is uniform in the size of the system.

Consolidated Environmental and Social Data Facilitates Neighborhood-Level Health Studies in Philadelphia.

A wide range of datasets containing geographically distributed measures of the environment and social factors is currently available, and as low-cost sensors and other devices become increasingly used, the volume of these data will continue to grow. Because such factors influence many health outcomes, researchers with varied interests often repeat tasks related to gathering and preparing these data for studies. We created Sensor-based Analysis of Pollution in the Philadelphia Region with Information on Neighborhoods and the Environment (SAPPHIRINE), offered as a web application and package, to integrate pollution, crime, social disadvantage, and traffic data relevant to investigators, citizen scientists, and policy makers in the Greater Philadelphia Area.

Feasibility and acceptability of monitoring personal air pollution exposure with sensors for asthma self-management.

Background: Exposure to fine particulate matter (PM) increases the risk of asthma exacerbations, and thus, monitoring personal exposure to PM may aid in disease self-management. Low-cost, portable air pollution sensors offer a convenient way to measure personal pollution exposure directly and may improve personalized monitoring compared with traditional methods that rely on stationary monitoring stations. We aimed to understand whether adults with asthma would be willing to use personal sensors to monitor their exposure to air pollution and to assess the feasibility of using sensors to measure real-time PM exposure.

Quick and Clean: LCME Scientific Method Training Without a Teaching Laboratory.

This exercise satisfies the Liaison Committee on Medical Education Standard 7.3 for medical student training in the scientific method. The students are challenged, individually and in small groups, to state and test hypotheses based on real patient data concerning risk factors for the development of hepatocellular carcinoma.

Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women.

Introduction: Sex-specific differences affect multiple aspects of HIV infection, yet few studies have quantified HIV levels in tissues from women. Since an HIV functional cure will likely require a major reduction of infected cells from most tissues, we measured total and intact HIV DNA and the HIV transcription profile in blood, gut, genital tract and liver from HIV-positive antiretroviral therapy (ART) -treated women.

Methods: Peripheral blood mononuclear cells (PBMC) and biopsies from the gastrointestinal (ileum, colon, rectosigmoid +/- liver) and genital (ectocervix, endocervix and endometrium) tracts were collected from 6 ART-treated (HIV RNA < 200 copies/mL) women.

Impact of Individual versus Geographic-Area Measures of Socioeconomic Status on Health Associations Observed in the Behavioral Risk Factor Surveillance System.

Efforts to enhance Electronic Health Record (EHR) data for the study of conditions in which social and economic variables play a prominent role include linking clinical data to sources of external information via patient-specific geocodes. This approach is convenient, but whether geographic-area-level information from secondary sources is adequate as a surrogate of individual-level information is not fully understood. We used Behavioral Risk Factor Surveillance System (BRFSS) epidemiologic data to compare associations of individual income, median aggregate income, and Area Deprivation Index (ADI)-a validated score of U.

Reproductive tract immune cells from pregnant women or those using depot medroxyprogesterone acetate show no excess susceptibility to HIV-1: Results of an ex vivo fusion assay.

Introduction: Ex vivo fusion assays offer an efficient method for studying HIV-1 entry associated with contraceptive use and pregnancy outside of cohort studies of HIV-1 incidence.

Methods: We measured ex vivo HIV-1 fusion to cervical or endometrial immune cells from three groups of women: pregnant, non-pregnant not using hormonal or intrauterine contraception, and using depot medroxyprogesterone acetate (DMPA).

Results And Conclusions: There was no excess susceptibility to HIV-1 fusion of cells from pregnant women or DMPA users compared to controls.

Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women.

Problem: The effects of HIV on the gastrointestinal tract (GIT), including CD4 depletion, epithelial disruption, and collagen deposition, are well documented and only partially reversed by combination antiretroviral therapy (cART). However, the effects of HIV on the female reproductive tract (FRT) are poorly understood, and most studies have focused on ectocervix and vagina without assessing the upper tract. Here, we investigated CD4 T-cell frequency, phenotype, and HIV-specific T-cell responses in the endocervix and endometrium of HIV-infected women, comparing these tissues to the GIT.

Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions.

Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of administration, little is known about their effects on the endometrial transcriptome in the presence or absence of estrogen. Herein, we assessed the transcriptome and pathways induced by progesterone (P) and the three most commonly used synthetic progestins, medroxyprogesterone acetate (MPA), levonorgestrel (LNG), and norethindrone acetate (NETA), on human endometrial stromal fibroblasts (eSF), key players in endometrial physiology and reproductive success.

Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women.

rs73208473 was recently associated with decreased atazanavir (ATV) concentration in the hair of women with seropositive HIV. Herein, we report on a pharmacogenetic study of women with seropositive HIV demonstrating a similar association between rs73208473 and dose-adjusted plasma ATV concentration in African Americans.

Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo.

Globally, HIV/AIDS is a leading cause of morbidity worldwide among reproductive-aged cisgender women, highlighting the importance of understanding effects of contraceptives on HIV-1 risk. Some observational studies suggest there may be an increased risk of HIV-1 acquisition among women using the long-acting injectable progestin contraceptive, depo-medroxyprogesterone acetate. The potential mechanism of this susceptibility is unclear.

Genetic and clinical predictors of CD4 lymphocyte recovery during suppressive antiretroviral therapy: Whole exome sequencing and antiretroviral therapy response phenotypes.

Increase of peripheral blood CD4 lymphocyte counts is a key goal of combined antiretroviral therapy (cART); most, but not all, recipients respond adequately and promptly. A small number of studies have examined specific genetic factors associated with the extent of CD4 recovery. We report a genome-wide examination of factors that predict CD4 recovery in HIV-infected women.

Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection.

Study Objective: To evaluate the association between use of methadone, other central nervous system (CNS) depressants, and QTc interval-prolonging medications and risk of mortality among human immunodeficiency virus (HIV)-infected and at-risk HIV-uninfected women.

Design: Multicenter, prospective, observational cohort study (Women's Interagency HIV Study [WIHS]).

Participants: A total of 4150 women enrolled in the WIHS study between 1994 and 2014 who were infected (3119 women) or not infected (1031 women) with HIV.

Facilitating Inclusion of Geocoded Pollution Data into Health Studies.

Exposure to pollutants impacts health and has been associated with a range of diseases, including respiratory and heart diseases, as well as all-cause mortality. Because taking exposure measures for individual studies is costly and impractical, most rely on data from sources such as the Environmental Protection Agency (EPA), which provides a wealth of publicly available pollution measures taken at over two thousand monitoring sites across the United States. While EPA data is readily available, estimating pollution exposure at a given latitude-longitude location remains computationally intensive.

Viremia Trajectories of HIV in HIV-Positive Women in the United States, 1994-2017.

Importance: Viral suppression of HIV is an important treatment goal to decrease morbidity, mortality, and risk of transmission to others.

Objective: To characterize longitudinal HIV viral load outcomes among women enrolled in the Women's Interagency HIV Study (WIHS).

Design, Setting, And Participants: A prospective cohort study of HIV-positive women with semiannual study visits and a minimum of 5 follow-up visits was conducted from 1994 to 2017.

HIV infection is an independent risk factor for decreased 6-minute walk test distance.

Background: Ambulatory function predicts morbidity and mortality and may be influenced by cardiopulmonary dysfunction. Persons living with HIV (PLWH) suffer from a high prevalence of cardiac and pulmonary comorbidities that may contribute to higher risk of ambulatory dysfunction as measured by 6-minute walk test distance (6-MWD). We investigated the effect of HIV on 6-MWD.

Factors associated with exacerbations among adults with asthma according to electronic health record data.

Background: Asthma is a chronic inflammatory lung disease that affects 18.7 million U.S.

Tropheryma whipplei colonization in HIV-infected individuals is not associated with lung function or inflammation.

Studies demonstrate that Tropheryma whipplei (T. whipplei) is present in the lungs of healthy individuals without acute respiratory symptoms or acute respiratory infection and is more common in the lungs of HIV-infected individuals and in smokers. The impact of T.

Prolonged Amenorrhea and Resumption of Menses in Women with HIV.

Objective: To compare etiologies of prolonged amenorrhea in a cohort of HIV-infected women with a cohort of similar uninfected at-risk women.

Materials And Methods: Women from the Women's Interagency HIV Study were seen every 6 months, and completed surveys including questions about their menstruation. Those who reported no vaginal bleeding for at least 1 year ("prolonged amenorrhea") with subsequent resumption of bleeding were compared with women in whom bleeding had stopped permanently ("menopause").

Factors Associated With Progression of Lung Function Abnormalities in HIV-Infected Individuals.

Background: HIV is an independent risk factor for chronic obstructive pulmonary disease; however, baseline risk factors for lung function decline remain largely unknown in this population.

Methods: HIV-infected participants in the Pittsburgh Lung HIV Cohort with at least 3 pulmonary function measurements between 2007 and 2016 were included. Pulmonary function testing including postbronchodilator (BD) spirometry and diffusion capacity for carbon monoxide (DLco) was performed every 18 months.

Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model.

Background: Human microbiome studies in clinical settings generally focus on distinguishing the microbiota in health from that in disease at a specific point in time. However, microbiome samples may be associated with disease severity or continuous clinical health indicators that are often assessed at multiple time points. While the temporal data from clinical and microbiome samples may be informative, analysis of this type of data can be problematic for standard statistical methods.