Exploring the effects of decabromodiphenyl ether on meiofaunal communities: An experimental approach.

This study investigates the ecotoxicological effects of BDE-209, a persistent organic pollutant (POP), prevalent in Kuwait's coastal-industrial zones, on meiofaunal communities. A mesocosm experiment was conducted, exposing sediment-dwelling meiofaunal communities from sediments near Failaka Island (Kuwait) to gradient concentrations of BDE-209 (0.01-20 mg/kg) over a 4-week period.

Axillary surgery versus no-axillary staging in T1N0 breast cancer: 20-year follow-up of the INT 09/98 randomized clinical trial.

Background: The role of axillary surgery in breast cancer has shifted over time from a therapeutic operation to a staging method for subsequent adjuvant therapies, through the introduction of sentinel lymph node biopsy. The discovery of molecular subtypes has since questioned the necessity of axillary staging in breast cancer.

Methods: The INT09/98 randomized trial explored the omission of axillary surgery in early-stage breast cancer in patients under 65 years of age.

Preferences for thromboprophylaxis in the intensive care unit: An international survey.

Background: Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis is widely applied to lower this risk, but guidelines lack dosing recommendations.

Objective: This survey aims to assess current thromboprophylaxis preferences and willingness to participate in future randomized clinical trials (RCTs) on this topic.

Real-world adherence to erenumab, rescue medication utilization, and work absenteeism for patients with migraine: Results from an outcomes-based agreement.

Background: Migraine prevalence is estimated to be 15% (approximately 50 million people) in the United States, posing a significant burden on the health care system and a top cause of years lived with disability. Consequently, migraine leads to increased work-related disability, including presenteeism and absenteeism. Novel prophylactic treatments for migraine that target the calcitonin gene-related peptide pathway, including monoclonal antibodies to the calcitonin gene-related peptide ligand or the calcitonin gene-related peptide receptor (calcitonin gene-related peptide monoclonal antibodies) and gepants, offer new options for migraine prevention.

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36 TeV with the ATLAS Detector at the LHC.

This Letter presents a search for highly ionizing magnetic monopoles in 262  μb^{-1} of ultraperipheral Pb+Pb collision data at sqrt[s_{NN}]=5.36  TeV collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion data.

Mycotoxigenic fungi, OTA and fumonisin B2 production by Aspergillus section Nigri isolated from wine grapes and natural occurrence of OTA in wines of Northern Argentinean Patagonia.

The Northern Argentinean Patagonia is the southernmost producing region of wine grapes and wine in Argentina. Their wines possess distinctive features due to the wide variety of red and white grapes and weather conditions, achieving great acceptance in local and international markets. The aims of the present study were to determine and characterize the mycobiota present in wine grapes from Northern Patagonia, to analyse the ability of the isolates to produce mycotoxins, and to determine the natural occurrence of OTA and monitoring its presence in wine over time.

Wearable devices for patient monitoring in the intensive care unit.

Wearable devices (WDs), originally launched for fitness, are now increasingly recognized as valuable technologies in several clinical applications, including the intensive care unit (ICU). These devices allow for continuous, non-invasive monitoring of physiological parameters such as heart rate, respiratory rate, blood pressure, glucose levels, and posture and movement. WDs offer significant advantages in making monitoring less invasive and could help bridge gaps between ICUs and standard hospital wards, ensuring more effective transitioning to lower-level monitoring after discharge from the ICU.

A Survey on the Prescribing Orientation Towards Complementary Therapies Among Oncologists in Italy: Symptoms and Unmet Patient Needs.

Background/aim: A high percentage of cancer patients use complementary therapies (CM) during their disease journey. Several barriers for CM prescription still exist among oncologists. This study explored oncologists' attitudes toward prescribing CM with oral supplements or confirming prescriptions made by others.

MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study.

Sarcopenia is exceedingly frequent in end-stage kidney disease (ESKD) patients on dialysis, including those undergoing peritoneal dialysis (PD), and is of multifactorial origin. MOTS-c is a mitochondrial-derived peptide that promotes muscle growth whose levels are unbalanced in ESKD. In this study, we evaluated MOTS-c balance and its relationship with sarcopenia risk in an ESKD-PD cohort.

Orbital Radiotherapy for Graves' Ophthalmopathy: Single Institutional Experience of Efficacy and Safety.

Unlabelled: Graves' ophthalmopathy is the most common extrathyroidal manifestation of Graves-Basedow disease. Radiotherapy is effective especially when used in synergy with the administration of glucocorticoids. The aim of our study was to analyze the effectiveness and safety of radiotherapy, using different protocols, to improve ocular symptoms and quality of life.

Perioperative assessment and management of frailty in elderly patients: a national survey of Italian anesthesiologists.

Background: The prevalence of frailty is increasing as the global population continues to age. Frailty is associated with poor perioperative outcomes including increased morbidity and mortality. The purpose of this study is to examine current practices and perspectives of anesthesiogists in Italy on the provision of care for elderly surgical patients with frailty.

Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD.

Background: Chronic kidney disease (CKD) has now reached pandemic proportions but risk prediction towards end-stage kidney disease (ESKD) remains challenging. Kidney fibrosis is a key determinant in the transition from CKD to ESKD. In this prospective study, we investigated the prognostic significance of urinary Marinobufagenin (uMBG), a cardiotonic steroid with acknowledged pro-fibrotic activity, for stratifying the risk of CKD progression in individuals with non-advanced renal disease.

Latest Advancements in the Management of H3K27M-Mutant Diffuse Intrinsic Pontine Glioma: A Narrative Review.

Despite recent advancements in radiotherapy for Diffuse Intrinsic Pontine Glioma (DIPG), the prognosis of this disease remains poor, highlighting the need for new treatment strategies to improve outcomes. Adding stereotactic biopsy to the diagnostic process for children with DIPG has been crucial in improving the management of this disease. Indeed, the discovery of the H3K27M mutation as a key driver of DIPG has led to the development of new drugs that are more effective than traditional ones.

Access to health services by women subjected to violence: findings from administrative healthcare data from the metropolitan area of northern Italy.

Background: In Italy, approximately 50% of women report experiencing episodes of psychological and/or physical violence. The Emergency Department (ED) is widely recognized as one of the health services to which victims of violence seek treatment for injuries and within which situations of domestic violence and abuse can be recognized. This work aims to estimate the phenomenon of violence in the population of the Health Protection Agency (ATS) of Milan using data from emergency room access and hospital admissions.

MAIT cells protect against sterile lung injury.

Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in sterile lung injury, is unknown. Using single-cell RNA sequencing (scRNA-seq), spectral analysis, and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and is associated with a protective role against bleomycin-induced lung injury.

Observation of Λ_{c}^{+}→Λa_{0}(980)^{+} and Evidence for Σ(1380)^{+} in Λ_{c}^{+}→Λπ^{+}η.

Based on 6.1  fb^{-1} of e^{+}e^{-} annihilation data collected at center-of-mass energies from 4.600 to 4.

Test of Lepton Universality and Measurement of the Form Factors of D^{0}→K^{*}(892)^{-}μ^{+}ν_{μ}.

One of the main goals of studying semileptonic decays in flavor physics is to gain a better understanding of hadronic transitions in the nonperturbative region of Quantum Chromodynamics. This involves measuring Cabibbo-Kobayashi-Maskawa matrix elements, understanding form factors, and comparing them with theoretical predictions. We report a first study of the semileptonic decay D^{0}→K^{-}π^{0}μ^{+}ν_{μ} by analyzing an e^{+}e^{-} annihilation data sample of 7.

Study of D_{s}^{+}→f_{0}(980)ρ^{+} and ϕπ^{+} Decays through D_{s}^{+}→π^{+}π^{+}π^{-}π^{0}.

We perform the first amplitude analysis of D_{s}^{+}→π^{+}π^{+}π^{-}π^{0} decays based on data samples of electron-positron collisions recorded with the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, corresponding to an integrated luminosity of 7.

Clinical and epidemiological characteristics of the 2022-2023 Mpox outbreak in Buenos Aires, Argentina.

Introduction: The 2022-2023 Mpox outbreak in Argentina presented unique challenges due to the lack of vaccination and antiviral therapy. This study analyzed the epidemiological and clinical characteristics of cases in the Buenos Aires Metropolitan Area (MABA), examining temporal trends, HIV status, and concomitant sexually transmitted infections (STIs).

Materials And Methods: An ambispective, analitic, and multicenter study was conducted between September 2022 and May 2023 in HIV/STI clinics and hospitals in MABA.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.

Enhancing emergency care for older persons: the role and impact of the electronic Frailty Index.

As the elderly population expands, enhancing emergency department (ED) care by assessing frailty becomes increasingly vital. To address this, we developed a novel electronic Frailty Index (eFI) from ED health records, specifically designed to assess frailty and predict hospitalization, in-hospital mortality, ICU admissions, and 30-day ED readmissions. This retrospective, single-center study included patients 65 years old or older who presented to the ED of IRCCS Humanitas Research Hospital in Milan, Italy, between January 2015 and December 2019.

β-Catenin/c-Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations.

Ammonia a by-product of nitrogen containing molecules is detoxified by liver into non-toxic urea and glutamine. Impaired ammonia detoxification leads to hyperammonemia. Ammonia has a dual role on autophagy, it acts as inducer at low concentrations and as inhibitor at high concentrations.

From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy.

In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. Recently, the therapeutic potential of this therapy has also been demonstrated in non-tumoral diseases. Currently, the manufacturing process to produce clinical-grade CAR-T cells is complex, time-consuming, and highly expensive.