Publications by authors named "Grazyna Suchodolska"
Introduction: Breast cancer (BC) is among the most frequently diagnosed malignant tumours in females. The optimal treatment of early HR+, HER2-, and lymph node-negative (N0) BC remains challenging. Since individual assessment of recurrence risk and expected benefits from adjuvant chemotherapy (CT) based on clinicopathological features alone appear inadequate, gene expression profiling tests have been developed.
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- Liquid biopsies, especially focusing on circulating tumor cells (CTCs) in blood, provide crucial insights into cancer spread, but current analysis is mainly limited to counting and basic marker profiling.
- A study analyzed CTCs' size, shape, and features from different cancers using advanced imaging methods, finding notable size and shape differences among at least four different cell types.
- Findings revealed that lung cancer produced the largest CTCs, while prostate and breast cancers had smaller ones, and distinct characteristics in cell shape corresponded to their epithelial or mesenchymal origins.
Circulating tumor cells (CTCs) and circulating cancer-associated fibroblasts (cCAFs) have been individually considered strong indicators of cancer progression. However, technical limitations have prevented their simultaneous analysis in the context of CTC phenotypes different from epithelial. This study aimed to analyze CTCs and cCAFs simultaneously in the peripheral blood of 210 breast cancer patients using DAPI/pan-keratin (K)/vimentin (V)/alpha-SMA/CD29/CD45/CD31 immunofluorescent staining and novel technology-imaging flow cytometry (imFC).
View Article and Find Full Text PDFBackground: The population of individuals affected by breast cancer is growing, and with advances in cancer treatment implemented into usual care, there is an urgent need to improve the recognition, monitoring and treatment of therapy-induced adverse effects. This study aims to explore the use of an in-app electronic questionnaire to assess and monitor chemotherapy-related symptoms in early breast cancer patients treated with perioperative chemotherapy.
Method: Between December 2019 and June 2021, 72 female study participants used the mobile app and completed an in-app questionnaire about the 14 most common chemotherapy-related symptoms.
Purpose: Early career researchers lack guidance about patient and public involvement (PPI). The overall aim of the study was to explore the knowledge and experiences of using PPI in research among doctoral students who are registered nurses.
Methods: This qualitative study included findings generated from reflective essays and focus groups involving ten registered cancer nurses who are undertaking doctoral research.
Background: Mobile applications are more and more often integrated into standard cancer care. Nevertheless, knowledge about the use of mobile applications for monitoring patients during treatment for early breast cancer is still limited.
Methods: A scoping review of literature was performed based on Joanna Briggs Institute guidelines to identify articles providing information on development and use of mobile applications for adult patients undergoing chemotherapy for early breast cancer.