Publications by authors named "Graziana Assalve"

Wearable technology has advanced significantly, offering real-time monitoring of athletes' physiological parameters and optimizing training and recovery strategies. Recent developments focus on biosensor devices capable of monitoring biochemical parameters in addition to physiological ones. These devices employ noninvasive methods such as sweat analysis, which reveals critical biomarkers like glucose, lactate, electrolytes, pH, and cortisol.

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Background: Oxidative stress, associated with diseases and aging, underscores the therapeutic potential of natural antioxidants. Flavonoids, known for scavenging free radicals and modulating cell signaling, offer significant health benefits and contribute to longevity. To explore their in vivo effects, we investigated the antioxidant activity of quercetin, apigenin, luteolin, naringenin, and genistein, using as a model organism.

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Differently from higher eukaryotic cells, in the yeast there are two mitochondrial carrier proteins involved in the transport of citrate: Ctp1 and Yhm2. Very little is known about the physiological role of these proteins. Wild-type and mutant yeast strains deleted in and were grown in media supplemented with a fermentable (glucose) or a nonfermentable (ethanol) carbon source.

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The mitochondrial citrate carrier (CIC) is a member of the mitochondrial carrier family and is responsible for the transit of tricarboxylates and dicarboxylates across the inner membrane. By modulating the flux of these molecules, it represents the molecular link between catabolic and anabolic reactions that take place in distinct cellular sub-compartments. Therefore, this transport protein represents an important element of investigation both in physiology and in pathology.

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Article Synopsis
  • The citrate carrier (CIC) is a protein in the inner mitochondrial membrane that moves citrate out of mitochondria into the cytosol, playing a key role in various metabolic processes.
  • Research has extensively analyzed the CIC's structure, function, and regulation across different organisms, revealing its complex impact on metabolism and physiology.
  • The review highlights the CIC's roles in cellular functions, how its activity is influenced by nutritional and hormonal states, and the importance of citrate movement between subcellular compartments.
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