Publications by authors named "Grassi Guido"
Chronic respiratory diseases (CRDs) are highly prevalent conditions, causing over 4 million deaths every year and representing a major source of physical, psychological, and occupational disability [...
View Article and Find Full Text PDFBackground And Aims: Evidence has been provided that in the normotensive population chronic coffee consumption does not adversely affect cardiovascular and total mortality. Whether and to what extent this is the case also in high risk cardiovascular patients such as those with elevated blood pressure (BP) is largely debated.
Methods And Results: We analyzed data collected in 943 hypertensive patients belonging to the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study, which were classified as coffee consumers and non-consumers (self report).
Background: In the absence of outcome-based ambulatory blood pressure (BP) trails hypertension guidelines provide 24-hour mean BP values corresponding to trial-validated office BP values. Data are shown for untreated and treated patients together, but whether corresponding ambulatory values are similar in untreated and treated hypertensives and reproducible at yearly measurements during treatment is undefined.
Methods: In 2397 patients of the ELSA (European Lacidipine Study on Atherosclerosis) and PHYLLIS (Plaque Hypertension Lipid-Lowering Italian Study) trials, we calculated the office and 24-hour BP relationship according to the linear regression model, with office systolic BP as the independent variable, at baseline and yearly during a 3-year treatment.
Effect of nebivolol monotherapy or combination therapy on blood pressure levels in patients with hypertension: an updated systematic review and multilevel meta-analysis of 91 randomized controlled trials.
High Blood Press Cardiovasc Prev
October 2024
Aims: To systematically appraise and summarize the available evidence from published randomized controlled trials considering the effect of nebivolol on blood pressure in patients with hypertension.
Methods: Literature search was performed through Medline (via PubMed), Cochrane Library and Scopus until December 15, 2023. Double-independent study selection, data extraction and quality assessment were performed.
Article Synopsis
- * It compared two groups of patients with treated hypertension: one group monitored during the pandemic and another monitored before it, looking at changes in hypertension phenotypes like sustained uncontrolled hypertension (SUCH) and sustained controlled hypertension (SCH).
- * Results showed no significant changes in the pandemic group’s hypertension phenotypes, while the pre-pandemic group saw an increase in SCH and a decrease in SUCH, suggesting the pandemic negatively impacted blood pressure management.
Article Synopsis
- The study investigated how the COVID-19 pandemic affected blood pressure control in patients with hypertension using ambulatory blood pressure monitoring (ABPM).
- Data were compared between two groups: patients measured before the pandemic and those measured during it, with a total of 704 pandemic patients and 916 prepandemic patients included in the analysis.
- Results showed that during the pandemic, patients had higher blood pressure readings and a greater prevalence of uncontrolled hypertension, highlighting the need for strategies to manage blood pressure during such crises.
Myocardial Mechanics in Acromegaly: A Meta-Analysis of Echocardiographic Studies.
High Blood Press Cardiovasc Prev
September 2024
Article Synopsis
- A meta-analysis was conducted to examine the left ventricular systolic function in acromegaly patients using global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE).
- The analysis included seven studies and found that while left ventricular ejection fraction (LVEF) was similar between acromegaly patients and healthy controls, the GLS in acromegaly patients indicated a borderline significant impairment.
- The study suggests the potential of GLS to reveal early systolic function issues in acromegaly, urging further research to confirm its effectiveness compared to LVEF.
Article Synopsis
- Anorexia nervosa (AN) is associated with cardiac complications, but limited research has examined how it affects heart muscle deformation without overt systolic dysfunction, leading to this meta-analysis for deeper insights.
- The study involved systematic searches for relevant clinical studies that analyzed left ventricular (LV) mechanics in AN patients versus healthy individuals, focusing on metrics like left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS).
- The findings showed no significant difference in GLS between AN patients and controls, while apical strain was notably higher in AN patients, suggesting that standard measures may not fully capture subclinical heart issues in those with AN.
Article Synopsis
- - This study investigates the connection between arterial stiffness, left ventricular (LV) changes, and different blood pressure (BP) types in a community setting, using data from the PAMELA study with 491 participants.
- - Results indicated that sustained hypertension (SH) is significantly more prevalent among those with increased arterial stiffness and cardiac remodeling, with a fourfold higher risk compared to those without such organ damage.
- - The findings highlight the importance of assessing both vascular and cardiac health to improve the detection and management of sustained hypertension in the general population.
New Guidelines for Hypertension Diagnosis and Treatment: An European Perspective.
Rev Cardiovasc Med
February 2024
Article Synopsis
- The study investigates the link between resting heart rates above 70 beats/minute in type 2 diabetes mellitus (T2D) patients and increased cardiovascular risk, aiming to determine if this reflects heightened sympathetic nervous system activity.
- Results indicate that higher heart rates were associated with greater muscle sympathetic nerve activity (MSNA) and norepinephrine levels, suggesting a significant relationship between heart rate and sympathetic overdrive in T2D patients.
- The findings highlight the importance of monitoring heart rates in T2D, as they may help identify patients with increased sympathetic activity, warranting further research into lifestyle and medication strategies that could potentially mitigate this risk.
Article Synopsis
- - This study analyzed the link between metabolically healthy overweight/obese adults and major cardiovascular events (MACE) using data from 15,904 participants over 11.8 years, focusing on how LDL-cholesterol levels affect this relationship.
- - Among participants younger than 70, being overweight/obese raised the risk of MACE significantly, while older adults had a lower risk despite having high BMI.
- - Including LDL-cholesterol in the definition of healthy metabolism showed that metabolically healthy overweight/obese individuals have no increased risk of MACE compared to normal weight individuals, challenging standard assessments of health risk.
Article Synopsis
- The study examined the relationship between Cardio-Ankle Vascular Index (CAVI) and nocturnal blood pressure (BP) fall in 491 participants from the PAMELA study after 10 and 25 years.
- It found that while both CAVI and left ventricular mass index (LVMI) were correlated with nocturnal SBP fall, only LVMI remained significant after adjusting for age and sex.
- The results suggest that CAVI is not linked to the degree of nighttime BP drop, but it can help identify nocturnal hypertension and improve cardiovascular risk assessment in the general population.
High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been recently postulated. Subjects from the URic acid Right for heArt Health (URRAH) study with carotid ultrasound and without previous cardiovascular diseases (CVD) (n = 6209), followed over 20 years, were included in the analysis.
View Article and Find Full Text PDFObjective Real-life management of patients with hypertension and chronic kidney disease (CKD) among European Society of Hypertension Excellence Centres (ESH-ECs) is unclear : we aimed to investigate it. Methods A survey was conducted in 2023. The questionnaire contained 64 questions asking ESH-ECs representatives to estimate how patients with CKD are managed.
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