Portable biomedical devices: a critical issue during telecare services design.

Objectives: The selection of a portable biomedical device (PBD) is a key issue regarding telecare service design. The objective of this study is to investigate the accuracy parameters of a PBD under different settings and levels.

Methods And Materials: By using a commercial PBD, trials were performed in a referral cardiology center and on the Olympia Explorer of the Royal Olympia Cruises, and the Superfast XII of Superfast Ferries.

Network design for telemedicine--e-health using satellite technology.

Over the last decade various international Information and Communications Technology networks have been created for a global access to high-level medical care. OP 2000 has designed and validated the high-end interactive video communication system WinVicos especially for telemedical applications, training of the physician in a distributed environment, teleconsultation and second opinion. WinVicos is operated on a workstation (WoTeSa) using standard hardware components and offers a superior image quality at a moderate transmission bandwidth of up to 2 Mbps.

Collaborative work during interventional radiological procedures based on a multicast satellite-terrestrial network.

Collaboration is a key requirement in several contemporary interventional radiology procedures (IRPs). This work proposes a multicast hybrid satellite system capable of supporting advanced IRP collaboration, and evaluates its feasibility and applicability. Following a detailed IRP requirements study, we have developed a system which supports IRP collaboration through the employment of a hybrid satellite-terrestrial network, a prototype multicast version of wavelet based interactive communication system (WinVicos) application, and a partition aggregation and conditional coding (PACC) wavelet codec.

New trends in the virtualization of hospitals--tools for global e-Health.

The development of virtual hospitals and digital medicine helps to bridge the digital divide between different regions of the world and enables equal access to high-level medical care. Pre-operative planning, intra-operative navigation and minimally-invasive surgery require a digital and virtual environment supporting the perception of the physician. As data and computing resources in a virtual hospital are distributed over many sites the concept of the Grid should be integrated with other communication networks and platforms.

Virtual hospital and digital medicine--why is the GRID needed?

The promise of telemedicine to enable equal access to high-level medical care can only be realised by the development of virtual hospitals, digital medicine and a bridging of the digital divide between the various regions of the world. For this, the concept of the Grid should be integrated with other communication networks and platforms. A promising approach is the implementation of service-oriented architectures for an invisible grid, hiding complexity for both application developers and end-users.

VEMH - Virtual Euro-Mediterranean Hospital for Global Healthcare.

The Virtual Euro-Mediterranean Hospital (VEMH) aims to facilitate the interconnection of various medical services through real integration. VEMH will provide an integrated satellite-terrestrial platform and realize telemedical services such as e-learning, real-time telemedicine and medical assistance and offer individual grants to young medical doctors. The methodologies of the VEMH are medical-need-oriented instead of technology-oriented.

Interactive telemedicine as a tool to avoid a digital divide in the world.

An efficient way of closing the gap in medical care between the EU and its Mediterranean partners is the use of satellite-based networks for telemedical applications. Using standard hardware components and specially designed communication software (WinVicos) various telemedical applications (teleconsultation, telementoring, teleteaching, etc.) have been realized.

[Interdisciplinary surgery and telemedicine].

Surgical therapy is becoming increasingly complex. Besides new surgical techniques, sophisticated diagnostic methods and innovative interventional procedures must be integrated into the therapeutic concept to increase the efficacy of surgery. Accurate application of these techniques requires close cooperation between surgeons, other medical specialists, and technicians.

Interactive telemedical applications in OP 2000 via satellite.

Using off-the-shelf hardware components and a specially developed high-end software communication system (WinVicos) satellite networks for interactive telemedicine have been designed and developed. These networks allow for various telemedical applications, like teleteaching, telementoring, intraoperative teleconsultation, second opinioning, etc..

Interactive telemedicine in the operating theatre of the future.

An experimental stereoscopic system has been established in the Robert-Rössle-Klinik, including four operating theatres and the surgical research unit OP 2000. The system allows local three-dimensional image acquisition, local stereoscopic video display, in-house stereoscopic video transmission and stereoscopic links to external partners. The goal is to make high-quality patient data available in a medical centre or over a collaborative network of medical experts.

Telemedicine: the new must for surgery.

The vision of telesurgery comprises a multitude of new communicative elements influencing the way surgeons will treat their patients in the future. The first prerequisite for effective telecommunication is to digitize surgical data. Many medical imaging modalities provide primarily digital data sets, and digital image communication is already entering clinical practice under the labels of teleradiology and telepathology.

[Telecommunication in routine surgical practice].

In an internal inquiry on the use of telecommunication, 267 operations were documented. In 62 cases an interruption was necessary: 43 of them for a second opinion and 29 for a new orientation resulting from findings, and in 10 cases for both. A purely verbal communication/consultation was sufficient in 8 cases, in 29 questions an on-site demonstration was necessary to come to a decision.

[Virtual operations on real patients].

The tremendous amount of available medical digital data requires media for intuitive information perception. Virtual reality (VR) presents a technique for processing the visual data from various diagnostic modalities. From a synthetic patient model, the required compact information can be generated.

[Teleconference and telesurgery].

Interchange of information has become possible independent of the user's place or time by modern telemedical services and opens up new dimensions for diagnostic and therapeutic procedures. For teleconferences and teleconsultations in surgery, the intraoperative high-quality transmission of live images is essential without disturbing the sterility and operation routine. The clinical specifications require special systems for broadband, stereoscopic online image transmission both intra- and inter-institutionally.

A chemical dosimeter for the determination of the photodynamic activity of photosensitizers.

Uric acid a known singlet oxygen scavenger, was investigated as a chemical dosimeter in physiological aqueous solution for use in photodynamic therapy. The uric acid test takes the decrease in uric acid (UA) absorbance at 293 nm after laser light irradiation of a solution containing UA and a photosensitizer as a rapid evaluation of relative photodynamic activities of the photosensitizer. A uric acid test standard procedure was defined.

[Techniques in teleconsultation].

The aim of the new developments in telemedicine is to optimize medical care by the use of new communication technologies. Teleconsultation is a basic component of telemedicine. Telepresence systems demand high-quality video transmissions and interactive communication.

31P NMR studies of cultured human tumor cells. Influence of pH on phospholipid metabolite levels and the detection of cytidine 5'-diphosphate choline.

202 MHz 31P NMR (11.7 T) was used to study the effects of culture medium pH on the levels of phosphate metabolites in three human tumor cell lines (XP29MAmal, a malignant xeroderma pigmentosum; CX-1, a colon carcinoma; KB, a squamous cell carcinoma of the oral cavity). Cells were cultured in Roux flasks in HAM's F-12 medium, and the pH was varied with the final medium change.

Synthesis of positively charged phthalocyanines and their activity in the photodynamic therapy of cancer cells.

Positively charged zinc containing or metal free phthalocyanines 6a-c and 7a-c were prepared via a three step procedure starting from 4-nitrophthalonitrile. The phthalocyanines contain alkyl chains of different length in order to influence the hydrophilic vs lipophilic character of the compounds. The partition between a hydrophilic (water) and lipophilic (octanol-1) phase was determined, and the photoredox activities were investigated.