Feasibility of home blood pressure screening in the paediatric outpatient clinic setting.

Objective: The aim of this study was to evaluate the acceptability and feasibility of home-based blood pressure (BP) screening in a group of paediatric patients with known elevated risk of developing hypertension.

Design: Cross-sectional study.

Setting: Specialist outpatient clinic and patient homes.

Exploring the relationship between trunk muscles and lower limb injuries in Australian badminton players.

Due to its dynamic nature, lower limb injuries are common in badminton. Overuse injuries of the knee, including tendon related conditions, are the most common. During jumping and landing, force transference and dissipation through the trunk is required, with the trunk muscles playing a vital role.

Predicted genetic burden and frequency of phenotype-associated variants in the horse.

Disease-causing variants have been identified for less than 20% of suspected equine genetic diseases. Whole genome sequencing (WGS) allows rapid identification of rare disease causal variants. However, interpreting the clinical variant consequence is confounded by the number of predicted deleterious variants that healthy individuals carry (predicted genetic burden).

Perceived Impact of Digital Health Maturity on Patient Experience, Population Health, Health Care Costs, and Provider Experience: Mixed Methods Case Study.

Background: Health care organizations understand the importance of new technology implementations; however, the best strategy for implementing successful digital transformations is often unclear. Digital health maturity assessments allow providers to understand the progress made toward technology-enhanced health service delivery. Existing models have been criticized for their lack of depth and breadth because of their technology focus and neglect of meaningful outcomes.

Genetic Variation and the Distribution of Variant Types in the Horse.

Genetic variation is a key contributor to health and disease. Understanding the link between an individual's genotype and the corresponding phenotype is a major goal of medical genetics. Whole genome sequencing (WGS) within and across populations enables highly efficient variant discovery and elucidation of the molecular nature of virtually all genetic variation.

Trunk muscle size and function in volleyball players with and without injuries to the head, neck and upper limb.

Objective: To investigate trunk muscle size and function in elite and community volleyball players with and without a history of head, neck or upper limb injury.

Design: Cross-sectional observational study.

Setting: Volleyball training camp or training sessions.

Does blood flow restriction training enhance clinical outcomes in knee osteoarthritis: A systematic review and meta-analysis.

Objective: To systematically review the efficacy of blood flow restriction training (BFRT) on individuals with knee osteoarthritis (OA).

Design: Systematic review with meta-analysis.

Literature Search: Eight electronic databases were searched by one researcher.

Clinical utility of measuring the size of the lumbar multifidus and quadratus lumborum muscles in the Australian football league setting: A prospective cohort study.

Objectives: Test the odds of factors previously associated with lower limb injury (decreased size of the multifidus (MF) and increased size of the quadratus lumborum (QL) muscle) in an independent sample of Australian Rules Football (ARF) players.

Design: Prospective cohort study.

Setting: Professional ARF.

Injury surveillance of an Australian community netball club.

Objectives: To describe injuries associated with netball and risk factors for lower limb injuries.

Design: Prospective study. In the preseason, risk factors were investigated using self-report questionnaires and physical measurements.

Association of Genetics and B Vitamin Status With the Magnitude of Optic Disc Edema During 30-Day Strict Head-Down Tilt Bed Rest.

Importance: Optic disc edema among astronauts after long-duration spaceflight is associated with 1-carbon pathway single-nucleotide polymorphisms and B vitamin status. A recent strict 6° head-down tilt bed rest (HDTBR) study documented development of optic disc edema and increased total retinal thickness in participants exposed to carbon dioxide, 0.5%, for 30 days, but genetic risk factors have not been explored in the cohort.

Closed-loop superluminal passive cavity.

We demonstrate the operation of a closed-loop fast-light cavity that allows rapid (~10 ms) measurements of the cavity mode frequency and its uncertainty. We vary the scale factor by temperature tuning the atomic density of an intracavity vapor cell. The cavity remains locked even as the system passes through the critical anomalous dispersion where a pole is observed in the scale factor.

Upwelling-driven nearshore hypoxia signals ecosystem and oceanographic changes in the northeast Pacific.

Seasonal development of dissolved-oxygen deficits (hypoxia) represents an acute system-level perturbation to ecological dynamics and fishery sustainability in coastal ecosystems around the globe. Whereas anthropogenic nutrient loading has increased the frequency and severity of hypoxia in estuaries and semi-enclosed seas, the occurrence of hypoxia in open-coast upwelling systems reflects ocean conditions that control the delivery of oxygen-poor and nutrient-rich deep water onto continental shelves. Upwelling systems support a large proportion of the world's fisheries, therefore understanding the links between changes in ocean climate, upwelling-driven hypoxia and ecological perturbations is critical.

Glutamine and asparagine synthesis in the nematodes Heligmosomoides polygyrus and Panagrellus redivivus.

Low levels of glutamine synthetase were demonstrated in Panagrellus redivivus and Heligmosomoides polygyrus. Asparagine synthetase was detected in P. redivivus but activity was too low to be detected in H.

Role of carnitine palmitoyltransferase I in the regulation of hepatic ketogenesis during the onset and reversal of chronic diabetes.

1. The kinetic properties of overt carnitine palmitoyltransferase (CPT I, EC 2.3.

Studies on the activation in vitro of carnitine palmitoyltransferase I in liver mitochondria from normal, diabetic and glucagon-treated rats.

The activation of overt carnitine palmitoyltransferase activity that occurs when rat liver mitochondria are incubated at near-physiological temperatures and ionic strengths was studied for mitochondria obtained from animals in different physiological states. In all instances, it was found to be due exclusively to an increase in the catalytic capacity of the enzyme and not to an increase in affinity of the enzyme for palmitoyl-CoA. The enzyme in mitochondria from fed animals always showed a larger degree of activation than that in mitochondria from starved animals.

Amino acid catabolism in the nematodes Heligmosomoides polygyrus and Panagrellus redivivus. 2. Metabolism of the carbon skeleton.

All of the enzymes of proline catabolism were present in Heligmosomoides polygyrus and Panagrellus redivivus and the activities were, in general, similar to those found in rat liver. Both nematodes were also shown to be able to catabolize the branched-chain amino acids leucine, isoleucine and valine, by pathways similar to those found in mammalian liver. There were no significant differences in amino acid catabolism between the animal-parasitic and free-living species of nematode.

Amino acid catabolism in the nematodes Heligmosomoides polygyrus and Panagrellus redivivus. 1. Removal of the amino group.

The major transaminase in Heligmosomoides polygyrus, Panagrellus redivivus and rat liver was the 2-oxoglutarate-glutamate system, with relatively few amino acids acting as donors for the pyruvate-alanine and oxaloacetate-aspartate systems. The relative effectiveness of the different amino acid donors in the three transaminase systems was similar in all three tissues. Both H.

Restoration of the properties of carnitine palmitoyltransferase I in liver mitochondria during re-feeding of starved rats.

The recovery of the parameters of the kinetic properties of carnitine palmitoyltransferase (CPT) I in liver mitochondria of starved rats was studied after re-feeding animals for various periods of time. There were no significant changes either in the activity of the enzyme at high palmitoyl-CoA concentrations or in the affinity of the enzyme for palmitoyl-CoA, or in the sensitivity of CPT I to malonyl-CoA inhibition after 3 h or 6 h re-feeding. After 24 h re-feeding, both the affinity of the enzyme for palmitoyl-CoA and the activity of the enzyme were still not significantly different from those for the enzyme in mitochondria from 24 h-starved animals.

Binding of [14C]malonyl-CoA to rat liver mitochondria after blocking of the active site of carnitine palmitoyltransferase I. Displacement of low-affinity binding by palmitoyl-CoA.

The active site of the overt activity of carnitine palmitoyltransferase (CPT I) in rat liver mitochondria was blocked by the self-catalysed formation of the S-carboxypalmitoyl-CoA ester of (-)-carnitine, followed by washing of the mitochondria. CPT I activity in treated mitochondria was inhibited by 90-95%. Binding of [14C]malonyl-CoA to these mitochondria was not inhibited as compared with that of control mitochondria.

Use of selected freshwater bivalves for monitoring organochlorine pesticide residues in major Mississippi stream systems, 1972-73.

Seven species of freshwater Pelecypoda, Amblema costata, Corbicula manilensis, Elliptio crassidens, lampsilis anadontoides, Lampsilis claibornensis, Megalonaias gigantea, and Plectomerus dombeyanus, were collected and monitored for pesticide content during 1972 and 1973. Thirteen collection sites, representing five major river basins in the state of Mississippi, were sampled and compared. During the 24-month study, 26 water samples and 58 claim samples from the five river basins were analyzed.

Fate of labeled n-alkanes in the blue crab and stripped mullet.

Results of these studies demonstrate that the blue crab was readily able to take up and discharge labeled n-alkanes, but it was not able to metabolize them. In contrast, it appears that n-alkanes taken up via the digestive tract in mullet are readily metabolized, probably via microorganisms in the gut. More limited metabolism was observed in mullet when n-alkanes were taken up via the gills.