Denosumab-Induced Maxillary Osteonecrosis: A Case Study on Long-Term Complications in Multiple Myeloma Treatment.

Targeted therapies like denosumab have revolutionized multiple myeloma (MM) treatment, improved patient outcomes while introducing long-term complications. This study explores a rare instance of delayed maxillary osteonecrosis post-denosumab therapy, delving into its pathophysiology and management. A 40-year-old male MM patient who developed a painful palatal lesion post denosumab treatment and diagnosed of maxillary osteonecrosis by computed tomography scan and surgical biopsy is presented.

Mobitz II Atrioventricular Block Following Intracardiac Radiation to the Right Ventricular Outflow Tract.

Cardiac complications from mediastinal radiotherapy are much more prevalent than in years past and are becoming a significant cause of morbidity and mortality in these patients following treatment. We describe a patient with metastatic lung adenosquamous carcinoma extending to the right ventricular outflow tract who would develop a Mobitz type II atrioventricular block following intracardiac radiation therapy requiring permanent pacemaker placement.

Candid and Fragile: A Case Report of Infective Endocarditis From Candida albicans and Bacteroides fragilis.

Infective endocarditis (IE) remains a significant cause of mortality worldwide and reported cases are continuing to increase annually. We describe a case of a patient who would undergo coronary artery bypass grafting (CABG) with bioprosthetic aortic valve replacement complicated by postop gastrointestinal bleeding requiring partial colectomy with ileocolic anastomosis who would later present with fever, dyspnea, and persistently positive blood cultures who would be found to have tricuspid valve endocarditis from and species that was successfully treated with a combination of surgical resection and antimicrobial therapy.

Combined large cell neuroendocrine carcinoma and squamous cell carcinoma of the oropharynx: A collision course of tumors.

Combined large cell neuroendocrine carcinoma (LCNEC) and squamous cell carcinoma (SCC) of the H&N are exceptionally rare. We present the case of combined p16 negative SCC and LCNEC of the oropharynx treated with combination chemotherapy. This is the third reported case of combined neuroendocrine carcinoma and SCC of the oropharynx.