Regeneration of the heart in diabetes by selective copper chelation.

Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Although altered systemic regulation of transition metals in diabetes has been the subject of previous investigation, it is not known whether changed transition metal metabolism results in heart disease in common forms of diabetes and whether metal chelation can reverse the condition. We found that administration of the Cu-selective transition metal chelator trientine to rats with streptozotocin-induced diabetes caused increased urinary Cu excretion compared with matched controls.

Oxygen abstraction by laser pyrolysis of W(CO)6; a mild route to gas-phase carbene chemistry.

SF6-photosensitiZed IR laser pyrolysis of W(CO)6 in the gas phase at moderate temperatures leads to unsaturated W(CO)n (n < 6) species; these prove to be effective abstractors of O atoms from a range of organic substrates, and afford a simple, clean and low-energy route from carbonyl compounds into gas phase carbene chemistry.