A machine learning-based multiscale model to predict bone formation in scaffolds.

Computational modeling methods combined with non-invasive imaging technologies have exhibited great potential and unique opportunities to model new bone formation in scaffold tissue engineering, offering an effective alternate and viable complement to laborious and time-consuming in vivo studies. However, existing numerical approaches are still highly demanding computationally in such multiscale problems. To tackle this challenge, we propose a machine learning (ML)-based approach to predict bone ingrowth outcomes in bulk tissue scaffolds.

A time-dependent mechanobiology-based topology optimization to enhance bone growth in tissue scaffolds.

Scaffold-based bone tissue engineering has been extensively developed as a potential means to treatment of large bone defects. To enhance the biomechanical performance of porous tissue scaffolds, computational design techniques have gained growing popularity attributable to their compelling efficiency and strong predictive features compared with time-consuming trial-and-error experiments. Nevertheless, the mechanical stimulus necessary for bone regeneration, which characterizes dynamic nature due to continuous variation in the bone-scaffold construct system as a result of bone-ingrowth and scaffold biodegradation, is often neglected.

Towards automated 3D finite element modeling of direct fiber reinforced composite dental bridge.

An automated 3D finite element (FE) modeling procedure for direct fiber reinforced dental bridge is established on the basis of computer tomography (CT) scan data. The model presented herein represents a two-unit anterior cantilever bridge that includes a maxillary right incisor as an abutment and a maxillary left incisor as a cantilever pontic bonded by adhesive and reinforced fibers. The study aims at gathering fundamental knowledge for design optimization of this type of innovative composite dental bridges.

Influence of core thickness on a restored crown of a first premolar using finite element analysis.

Purpose: This study examined the influence of ceramic coping thickness on the maximum stresses that arise in a first premolar all-ceramic crown.

Materials And Methods: Axisymmetric finite element models with different In-Ceram Alumina coping thicknesses (0.3, 0.

Influence of margin design and taper abutment angle on a restored crown of a first premolar using finite element analysis.

Purpose: The purpose of this study was to determine the influence of margin design and taper abutment angle on the stresses developed in all-ceramic first premolar crowns.

Materials And Methods: Four margin designs and three taper abutment angles were independently incorporated into models examined by finite element analysis. A 600-N force was applied vertically downward.

Influence of cement on a restored crown of a first premolar using finite element analysis.

Purpose: The purpose of this study was to examine the influence of the elastic modulus of cement and luting thickness on the resulting stresses in an axially loaded crown cemented onto a first premolar. A comparison of these stresses was also made with the strength of the constituent materials making up the crown.

Materials And Methods: Examination of the stresses on a restored crown was conducted using finite element analysis.

Finite element analysis studies of a metal-ceramic crown on a first premolar tooth.

Purpose: This study examined the stresses developed during loading in a first premolar metal-ceramic crown made of different metal cores, and used them to anticipate the locations and form of the most likely failure modes. The maximum principal stresses in the porcelain are indicators of fracture, and the von Mises stresses in the metal core are indicators of the location of yielding.

Materials And Methods: Two-dimensional axisymmetric models with different core metals were analyzed using finite element analyses.

Finite element analysis studies of an all-ceramic crown on a first premolar.

Purpose: This study examined the effects of using four different core-ceramic materials on the stresses that developed in a single all-ceramic first premolar crown.

Materials And Methods: This was done by analyzing models constructed in an axisymmetric fashion with finite element analyses. The model had a 600-N vertical load applied uniformly over a circular area on top of the crown.