Publications by authors named "Grant Goodrich"

An adolescent's last moment of life is an emotionally and medically complex time. Children may grapple with understanding the things happening to them and with grief of a future lost; caregivers struggle to simultaneously balance deep sorrow, hope, and love; and healthcare providers fight to maintain sound medical and ethical decision making. Increased discussion regarding adolescent end-of-life care is needed so that clinicians may better understand how to engage in ethically based medical management during these events.

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Conwy Lloyd Morgan (1852-1936) is widely regarded as the father of modern comparative psychology. Yet, Morgan initially had significant doubts about whether a genuine science of comparative psychology was even possible, only later becoming more optimistic about our ability to make reliable inferences about the mental capacities of non-human animals. There has been a fair amount of disagreement amongst scholars of Morgan's work about the nature, timing, and causes of this shift in Morgan's thinking.

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Traumatic brain injury is a leading cause of acquired epilepsy. Initially described in 1989, lateral fluid percussion injury (LFPI) has since become the most extensively used and well-characterized rodent traumatic brain injury and post-traumatic epilepsy model. Universal findings, particularly seizures that reliably develop after an initial latent period, are evident across studies from multiple laboratories.

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Article Synopsis
  • Excessive glutamate after traumatic brain injury (TBI) can lead to cell death and post-traumatic epilepsy, with GLT-1 being the primary glutamate transporter in the brain.
  • In a rat model of TBI, GLT-1 expression was found to be significantly reduced in the affected cortex, but treatment with ceftriaxone restored GLT-1 levels.
  • Ceftriaxone treatment also lowered astrogliosis markers and significantly decreased the duration of post-traumatic seizures, indicating its potential for TBI-related epilepsy management.
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