Publications by authors named "Grant Brooke"

Cervical cancer (CaCx) is a major public health issue, with over 600,000 women diagnosed annually. CaCx kills someone every 90 s, mostly in low- and middle-income countries. There are effective yet imperfect mechanisms to prevent CaCx.

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Article Synopsis
  • ctDNA (circulating tumor DNA) analysis shows promise in understanding endometrial cancer (EC), revealing significant genetic alterations in advanced/recurrent cases through a study of nearly 2000 patients.
  • The study identified that 91.6% of ctDNA samples had somatic mutations, with TP53 being the most frequently altered gene, linked to worse overall survival (OS) for patients.
  • Findings suggest that ctDNA testing is a feasible method and could serve as a potential biomarker for monitoring and improving outcomes in endometrial cancer patients.*
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Efforts are under way to define the role of minimally invasive strategies for molecular monitoring and risk stratification in endometrial cancer. A recent publication aims to define the association between circulating tumor DNA level and disease stage in patients with newly diagnosed endometrial cancer and determine whether sequencing of longitudinal cell-free DNA samples can be used for disease monitoring and detection of progression or recurrence. These results accelerate the current knowledge of molecular follow-up in endometrial cancer.

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House flies, Musca domestica L., (Diptera: Muscidae) mechanically vector diverse disease-causing microorganisms while foraging for food in agricultural and urban habitats. Although flies are diverse feeders, nutrient composition of food is important for both fly longevity and reproduction, especially for anautogenous females who require protein for egg production.

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Background: T-cell receptor gamma (TCR-gamma) is involved in maintaining host cell integrity and homeostasis of the human immune system. We hypothesize that polymorphism of the TCR-gamma complex may be involved in the pathogenesis of colorectal cancer.

Methods: The microsatellite markers D7S1818 and D7S2206 located within the TCR-gamma antigen locus on chromosome 7p were amplified by polymerase chain reaction, and genotypes were determined for 22 patients with early onset of colorectal cancer (<60 years old) and for 38 population-based control subjects.

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