Publications by authors named "Grant A Hartung"
Functional Positron Emission Tomography (fPET) with (bolus plus) constant infusion of [F]-fluorodeoxyglucose FDG), known as fPET-FDG, is a recently introduced technique in human neuroimaging, enabling the detection of dynamic glucose metabolism changes within a single scan. However, the statistical analysis of fPET-FDG data remains challenging because its signal and noise characteristics differ from both classic bolus-administration FDG PET and from functional Magnetic Resonance Imaging (fMRI), which together compose the primary sources of inspiration for analytical methods used by fPET-FDG researchers. In this study, we present an investigate of how inaccuracies in modeling baseline FDG uptake can introduce artifactual patterns to detrended TAC residuals, potentially introducing spurious (de)activations to general linear model (GLM) analyses.
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- About 20%-30% of adult diffusely infiltrative gliomas feature a mutation in the IDH1 gene, leading to high levels of D-2-hydroxyglutarate (D2HG) production, which can reach significant concentrations within the tumor.
- The study used liquid chromatography-mass spectrometry (LC-MS) to measure D2HG release from IDH1mut glioma cells and developed mathematical models to predict D2HG diffusion in the brain.
- Results showed that IDH1mut glioma cells release D2HG at varying rates, estimating high extracellular concentrations of D2HG (over 3 mM) near the tumor, which could influence the surrounding nonneoplastic cells. *