Publications by authors named "Grania Christyani"
The TopBP1-ATR axis is critical for maintaining genomic stability during DNA replication stress, yet the precise regulation of TopBP1 in replication stress responses remains poorly understood. In this study, we identified PHD and Ring Finger Domains 1 (PHRF1) as an important ATR activator through its interaction with TopBP1. Our analysis revealed a correlation between PHRF1 and genomic stability in cancer patients.
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- Cancer is the leading cause of death globally, with rare cancers having 230 unique subtypes that are hard to diagnose and treat due to their low occurrence rates.
- This review discusses advanced diagnostic methods like new-generation sequencing and multi-omics, enhanced by artificial intelligence and machine learning, which have improved rare cancer diagnosis.
- It also covers recent therapeutic advancements, including immunotherapy and targeted therapies, which have shown promise in clinical trials for improving patient survival and cancer remission, while addressing challenges in data interpretation and drug development.