The impact of relative word-length on effects of non-adjacent word transpositions.

A recent study (Wen et al., Journal of Experimental Psychology: Human Perception and Performance, 50: 934-941, 2024) found no influence of relative word-length on transposed-word effects. However, following the tradition of prior research on effects of transposed words during sentence reading, the transposed words in that study were adjacent words (words at positions 2 and 3 or 3 and 4 in five-word sequences).

Service evaluation of R90 bleeding and platelet disorders gene panel in thrombocytopenia cases.

This study examines the R90 bleeding and platelet disorders gene panel's utility in thrombocytopenia. The study analysed the correlations between the clinical features of patients with thrombocytopenia and genetic outcomes. The diagnostic yield was 46.

Letters, Words, Sentences, and Reading.

In this personal, and therefore highly selective, review article I summarize work performed in collaboration with numerous colleagues on how skilled adult readers perform identification tasks and speeded binary decision tasks involving single letters and visually presented words and sentences. The overarching aim is to highlight similarities in the processing performed at three key levels involved in written language comprehension (in languages that use an alphabetic script): letters, words, and sentences. The comparisons are made using behavioral data obtained with: i) speeded (response-limited) binary decision tasks; and ii) the effects of simultaneous surrounding context on letter and word identification using both data-limited (non-speeded) and response-limited procedures.

On relative word length and transposed-word effects.

It is harder to decide that a sequence of words is ungrammatical when the ungrammaticality is created by transposing two words in a correct sentence (e.g., he wants green these apples), and it is harder to judge that two ungrammatical word sequences are different when the difference is created by transposing two words (e.

Quality of life in childhood immune thrombocytopenia: Revision of the Kids' ITP Tools (KIT).

The Kids ITP Tools (KIT) is a health-related quality of life (HRQoL) questionnaire that evaluates quality of life in children with immune thrombocytopenia (ITP). There are three formats: Child Self-Report, Parent Proxy-Report and Parent Impact-Report. This study aimed to develop a domain structure by grouping-related questions from the questionnaire into domains that independently reflect various aspects of HRQoL.

Caplacizumab in pediatric immune thrombotic thrombocytopenic purpura: the UK TTP Registry experience.

Pediatric thrombotic thrombocytopenic purpura (TTP) is an ultrarare disease. Immune TTP (iTTP) is driven by anti-ADAMTS13 autoantibodies causing an imbalanced von Willebrand factor (VWF):ADAMTS13 axis, and rarer still in children, but potentially life-threatening. Caplacizumab is licensed for iTTP treatment in adults and adolescents aged ≥12 years who weigh ≥40 kg.

Phonological neighbors cooperate during spoken-sentence processing: Evidence from a nonword detection task.

We used a novel nonword detection task to examine the lexical competition principle postulated in most models of spoken word recognition. To do so, in Experiment 1 we presented sequences of spoken words with half of the sequences containing a nonword, and the target nonword (i.e.

Th17-to-Tfh plasticity during periodontitis limits disease pathology.

Th17 cell plasticity is crucial for development of autoinflammatory disease pathology. Periodontitis is a prevalent inflammatory disease where Th17 cells mediate key pathological roles, yet whether they exhibit any functional plasticity remains unexplored. We found that during periodontitis, gingival IL-17 fate-mapped T cells still predominantly produce IL-17A, with little diversification of cytokine production.

Sentence superiority in the reading brain.

When a sequence of written words is briefly presented and participants are asked to identify just one word at a post-cued location, then word identification accuracy is higher when the word is presented in a grammatically correct sequence compared with an ungrammatical sequence. This sentence superiority effect has been reported in several behavioral studies and two EEG investigations. Taken together, the results of these studies support the hypothesis that the sentence superiority effect is primarily driven by rapid access to a sentence-level representation via partial word identification processes that operate in parallel over several words.

The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype.

The murine bone marrow has a central role in immune function and health as the primary source of leukocytes in adult mice. Laboratory mice provide a human-homologous, genetically manipulable and reproducible model that has enabled an immeasurable volume of high-quality immunological research. However, recent research has questioned the translatability of laboratory mouse research into humans and proposed that the exposure of mice to their wild and natural environment may hold the key to further immunological breakthroughs.

On the distinction between position and order information when processing strings of characters.

To probe the processing of gaze-dependent positional information and gaze-independent order information when matching strings of characters, we compared effects of visual similarity (hypothesized to affect gaze-centered position coding) with the effects of character transpositions (hypothesized to affect the processing of gaze-independent order information). In Experiment 1, we obtained empirical measures of visual similarity for pairs of characters, separately for uppercase consonants and keyboard symbols. These similarity values were then used in Experiment 2 to create pairs of four-character stimuli (four letters or four symbols) that could differ by substituting one character with a different character from the same category that was visually similar (e.

Single and multi-dose pharmacology of recombinant and urinary human chorionic gonadotrophin in men.

Objective: Human choriogonadotrophin (hCG) treatment of gonadotrophin-deficient infertile men uses hCG of urinary (uhCG) or recombinant (rhCG) origin, but these treatments have not been compared nor are there studies defining rhCG dosing in men.

Design: hCG products were studied in randomized cross-over single-dose studies of standard (Study 1, 1500 IU and 62.5 µg, respectively) or high (Study 2, 5000 IU and 250 µg) dose and a multi-dose population pharmacology study of hCG use.

Prevalence of nandrolone preparations with endogenous carbon isotope ratios in Australia.

Nandrolone and its prohormones, including 19-norandrost-4-ene-3,17-dione and 19-norandrost-4-ene-3β,17β-diol, are anabolic steroids forbidden at all times in sports according to the World Anti-Doping Code Prohibited List and its metabolite 19-norandrosterone (19NA) is the preferred urinary target compound to identify their abuse. In recent years, an increasing number of 19NA isotope ratio mass spectrometry (IRMS) cases have arisen that, based on the initial testing procedure, were likely to result in an adverse analytical finding but were concluded negative after IRMS analysis. The current study was therefore set up to gain a better insight on the prevalence of nandrolone preparations with endogenous carbon isotope ratio values in Australia.

Effects of vertically aligned flankers during sentence reading.

We examine whether information lying above and below a line of text being read can impact on reading fluency. We did so by placing length-matched flankers above and below each word in a sequence of words. We found that identical flankers facilitated sentence reading, compared with syntactically correct different text flankers, in both reading-for-meaning (Experiment 1) and grammatical decisions (Experiment 2).

Rime Priming Effects in Spoken Word Recognition.

In this study, we re-examined the facilitation that occurs when auditorily presented monosyllabic primes and targets share their final phonemes, and in particular the rime (e.g., /vɔʀd/-/kɔʀd/).

The dynamics of multiword sequence extraction.

Being able to process multiword sequences is central for both language comprehension and production. Numerous studies support this claim, but less is known about the way multiword sequences are acquired, and more specifically how associations between their constituents are established over time. Here we adapted the Hebb naming task into a Hebb lexical decision task to study the dynamics of multiword sequence extraction.

Expert United Kingdom consensus on the preservation of joint health in people with moderate and severe haemophilia A: A modified Delphi panel.

Aim: For people with haemophilia A (PwHA), bleeding in the joints leads to joint damage and haemophilia-related arthropathy, impacting range of motion and life expectancy. Existing guidelines for managing haemophilia A support healthcare professionals (HCPs) and PwHA in their efforts to preserve joint health. However, such guidance should be reviewed, considering emerging evidence and consensus as presented in this manuscript.

Lexical competition in the flankers task revisited.

We investigated the impact of flanking stimuli that are orthographic neighbors of central target words in the reading version of the flankers task. Experiment 1 provided a replication of the finding that flanking words that are orthographic neighbors of central target words (e.g.

When phonological neighbours cooperate during spoken sentence processing.

This study examined for the first time the impact of the presence of a phonological neighbour on word recognition when the target word and its neighbour co-occur in a spoken sentence. To do so, we developed a new task, the verb detection task, in which participants were instructed to respond as soon as they detected a verb in a sequence of words, thus allowing us to probe spoken word recognition processes in real time. We found that participants were faster at detecting a verb when it was phonologically related to the preceding noun than when it was phonologically unrelated.

Helminths revive to survive.

Helminth parasites are well known to have co-evolved a diverse arsenal of immunomodulatory factors to aid their persistence following infection. In this issue, Karo-Atar et al. (2022.

Constraints on integration of orthographic information across multiple stimuli: effects of contiguity, eccentricity, and attentional span.

Five flanked lexical decision experiments investigated the integration of information across spatially distinct letter strings. Experiment 1 found no significant difference between quadrigram flankers (e.g.

The impact of atypical text presentation on transposed-word effects.

When asked to decide if an ungrammatical sequence of words is grammatically correct or not, readers find it more difficult to do so (longer response times (RTs) and more errors) if the ungrammatical sequence is created by transposing two words from a correct sentence (e.g., the white was cat big) compared with matched ungrammatical sequences where transposing two words does not produce a correct sentence (e.

Simple questions on simple associations: regularity extraction in non-human primates.

When human and non-human animals learn sequences, they manage to implicitly extract statistical regularities through associative learning mechanisms. In two experiments conducted with a non-human primate species (Guinea baboons, Papio papio), we addressed simple questions on the learning of simple AB associations appearing in longer noisy sequences. Using a serial reaction time task, we manipulated the position of AB within the sequence, such that it could be either fixed (by appearing always at the beginning, middle, or end of a four-element sequence; Experiment 1) or variable (Experiment 2).

Readers use word length information to determine word order.

It is assumed by the OB1-reader model that activated words are flexibly associated with spatial locations. Supporting this notion, recent studies show that readers can confuse the order of words. As word position coding is assumed to rely, among other things, on low-level visual cues, OB1 predicts that it must be harder to determine the order of words when these are of equal length, and consequently, that it is more difficult to read uniform word length sentences.