Publications by authors named "Graham Rix"
J Mol Med (Berl)
October 2024
Article Synopsis
- Severe burn injuries trigger a prolonged hypermetabolic response, leading to increased energy expenditure and multi-organ dysfunction due to elevated catecholamines, which cause detrimental changes in adipose tissue.
- Research shows that burn injuries induce endoplasmic reticulum (ER) stress and activate lipolysis in both epididymal and inguinal white adipose tissue (WAT) depots.
- Propranolol, a non-selective β-blocker, can alleviate these negative effects by reducing ER stress and lipolysis in burn-injured adipose tissue, suggesting its effectiveness as a therapeutic intervention.
