Publications by authors named "Graham Pickard"
Objectives: HTLV-1 is predominantly a sexually-transmitted infection but testing is not mentioned in HIV-PrEP guidelines. We ascertained HTLV-1/HTLV-2 seroprevalence amongst HIV-PrEP users in England.
Methods: An unlinked anonymous seroprevalence study.
Article Synopsis
- This study evaluates the immunogenicity and effectiveness of two COVID-19 vaccines (BNT162B2 and ChAdOx1) in patients undergoing haemodialysis, who are at higher risk for severe illness from COVID-19.
- The research involved 1021 haemodialysis patients, tracking their antibody responses and overall health post-vaccination, finding that BNT162B2 produced significantly higher antibody levels than ChAdOx1.
- The findings indicate that while both vaccines offered substantial protection against severe outcomes, antibody levels could predict the risk of breakthrough infections, suggesting that continuous monitoring of antibody responses could be beneficial in this vulnerable population.
Background: Solid organ transplant recipients have attenuated immune responses to SARS-CoV-2 vaccines. In this study, we report on immune responses to 3rd- (V3) and 4th- (V4) doses of heterologous and homologous vaccines in a kidney transplant population.
Methods: We undertook a single centre cohort study of 724 kidney transplant recipients prospectively screened for serological responses following 3 primary doses of a SARS-CoV2 vaccine.
Patients with end stage kidney disease receiving in-center hemodialysis (ICHD) have had high rates of SARS-CoV-2 infection. Following infection, patients receiving ICHD frequently develop circulating antibodies to SARS-CoV-2, even with asymptomatic infection. Here, we investigated the durability and functionality of the immune responses to SARS-CoV-2 infection in patients receiving ICHD.
View Article and Find Full Text PDFBackground: Routine diagnostic laboratories are confronted with an ever-increasing workload with limited resources. Automation has provided some solutions to these challenges particularly high through put analysers such as the Abbott AxSYM.
Objective: The aim of the present study was to compare the performance of two automated immunoassay systems in a diagnostic virology laboratory.